uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Toxic epidermal necrolysis and hemolytic uremic syndrome after allogeneic stem-cell transplantation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnonkologisk forskning/Lönnerholm)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2007 (English)In: Pediatric Transplantation, ISSN 1397-3142, E-ISSN 1399-3046, Vol. 11, no 6, 689-693 p.Article in journal (Refereed) Published
Abstract [en]

TEN and HUS are challenging complications with excessive mortality after HSCT. We report the development of these two conditions in combination in a nine-yr-old boy after HSCT from an unrelated donor. TEN with skin detachment of more than 90% of body surface area developed after initial treatment for GvHD. Within a few days of admission to the burns unit, the patient developed severe hemolysis, hypertension, thrombocytopenia, and acute renal failure consistent with HUS, apparently caused by CSA. The management included intensive care in a burns unit, accelerated drug removal using plasmapheresis, and a dedicated multi-disciplinary team approach to balance immunosuppression and infections management in a situation with extensive skin detachment. The patient survived and recovered renal function but requires continued treatment for severe GvHD. Suspecting and identifying causative drugs together with meticulous supportive care in the burns unit is essential in the management of these patients and long-term survival is possible.

Place, publisher, year, edition, pages
2007. Vol. 11, no 6, 689-693 p.
Keyword [en]
children, allogeneic stem cell transplantation, hemolytic uremic syndrome, toxic epidermal necrolysis, cyclosporine A, plasmapheresis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-85160DOI: 10.1111/j.1399-3046.2007.00743.xISI: 000249004000021PubMedID: 17663696OAI: oai:DiVA.org:uu-85160DiVA: diva2:113068
Available from: 2007-08-14 Created: 2007-08-14 Last updated: 2011-01-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Arvidson, JohanKildal, MortenLinde, TorbjörnGedeborg, Rolf

Search in DiVA

By author/editor
Arvidson, JohanKildal, MortenLinde, TorbjörnGedeborg, Rolf
By organisation
Department of Women's and Children's HealthDepartment of Surgical SciencesDepartment of Medical SciencesAnaesthesiology and Intensive Care
In the same journal
Pediatric Transplantation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 585 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf