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Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis
Uppsala University.
Uppsala University.
Uppsala University.
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1996 (English)In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, Vol. 93, no 9, 4480-4485 p.Article in journal (Other scientific) Published
Abstract [en]

Immunization of mice with rat type II collagen (CII), a cartilage-specific protein, leads to development of collagen-induced arthritis (CIA), a model for rheumatoid arthritis. To define the interaction between the immune system and cartilage, we produced

Place, publisher, year, edition, pages
NATL ACAD SCIENCES , 1996. Vol. 93, no 9, 4480-4485 p.
Keyword [en]
collagen-induced arthritis; T-cell tolerance; transgenic mice; autoimmunity; rheumatoid arthritis; MAJOR HISTOCOMPATIBILITY COMPLEX; TRANSGENIC MICE; RHEUMATOID-ARTHRITIS; SELF-TOLERANCE; GENE; MOUSE; AUTOIMMUNITY; ASSOCIATION; CHONDRODYSPLASIA; IDENTIFIC
Identifiers
URN: urn:nbn:se:uu:diva-85200OAI: oai:DiVA.org:uu-85200DiVA: diva2:113108
Note
Addresses: Malmstrom V, LUND UNIV, DEPT CELL & MOLEC BIOL, SECT MED INFLAMMAT RES, BOX 94, S-22100 LUND, SWEDEN. UNIV ERLANGEN NURNBERG, DEPT INTERNAL MED 3, W-8520 ERLANGEN, GERMANY. UNIV UPPSALA, DEPT ANIM DEV & GENET, UPPSALA, SWEDEN. TURKU UNIV, DEPTAvailable from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-15

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