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Genomic imprinting and mammalian development
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology. zoologisk utvecklingsbiologi.
1996 (English)In: PLACENTA, Vol. 17, no 1, 3-14 p.Article, review/survey (Other (popular scientific, debate etc.)) Published
Abstract [en]

Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself remain elusive but most likely include epigenetic modifications of DNA, such as methylation and chromatin structure changes. It is clear, however, that many of the known imprinted genes play important developmental roles and that changes in the functional imprinting of some of these genes may have important pathological consequences, including placental abnormalities.

Place, publisher, year, edition, pages
1996. Vol. 17, no 1, 3-14 p.
Keyword [en]
GROWTH FACTOR-II; X-CHROMOSOME INACTIVATION; CPG BINDING-PROTEIN; DNA METHYLATION; MOUSE DEVELOPMENT; PARENTAL NUCLEOSOMES; PATERNAL GENOMES; GENE-EXPRESSION; H19 GENE; REPLICATION
Identifiers
URN: urn:nbn:se:uu:diva-85207PubMedID: 8710810OAI: oai:DiVA.org:uu-85207DiVA: diva2:113115
Note
Addresses: Franklin GC, UPPSALA UNIV, DEPT ANIM DEV & GENET, NORBYVAGEN 18A, S-75236 UPPSALA, SWEDEN.Available from: 2007-02-12 Created: 2007-02-12 Last updated: 2011-01-15

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