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H19 is imprinted in the choroid plexus and leptomeninges of the mouse foetus
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolutionary Biology, Department of Animal Development and Genetics.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolutionary Biology, Department of Animal Development and Genetics.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Animal Development and Genetics.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Animal Development and Genetics.
1995 (English)In: Mechanisms of Development, ISSN 0925-4773, E-ISSN 1872-6356, Vol. 51, no 1, 31-37 p.Article in journal (Refereed) Published
Abstract [en]

It has been proposed that either the Igf-2 gene or the H19 gene — but not both — can be expressed from a given chromosome. Igf-2 is known to be biallelically expressed in the choroid plexus and leptomeninges, however, raising the question of whether H19 is down-regulated or absent there. We found by in situ hybridization that H19 is indeed expressed in the choroid plexus and leptomeninges of the developing mouse foetus. Comparison with the expression pattern of Igf-2 showed that the genes are coexpressed in all areas, with the exception of the choroid plexus epithelium. To evaluate whether H19 is also biallelically expressed in these tissues, we microdissected embryos from interspecific crosses and performed RNAse protection analysis on the isolated RNA. This revealed that H19 maintains its imprint in the choroid plexus/leptomeninges, being transcribed from the maternal allele at a level comparable to that in normal liver. We discuss the significance of these results for current models of Igf-2 and H19 imprinting.

Place, publisher, year, edition, pages
1995. Vol. 51, no 1, 31-37 p.
Keyword [en]
H19; IGF-2; MOUSE CHOROID PLEXUS LEPTOMENINGES; IMPRINTING; GROWTH FACTOR-II; GENE; ALLELE; RNA; H19-GENE
National Category
Developmental Biology
Identifiers
URN: urn:nbn:se:uu:diva-85223DOI: 10.1016/0925-4773(94)00345-NOAI: oai:DiVA.org:uu-85223DiVA: diva2:113131
Available from: 2007-02-15 Created: 2007-02-15 Last updated: 2017-12-14Bibliographically approved

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Fundele, ReinaldOhlsson, Rolf

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