Insights into the evolutionary process of genome degradation
1999 (English)In: Current Opinion in Genetics and Development, ISSN 0959-437X, E-ISSN 1879-0380, Vol. 9, no 6, 664-671 p.Article in journal (Refereed) Published
Studies of noncoding and pseudogene sequence diversity, particularly in Rickettsia, have begun to reveal the basic principles of genome degradation in microorganisms. Increasingly, studies of genes and genomes suggest that there has been an extensive amount of horizontal gene transfer among microorganisms. As this inflow of genetic material does not seem generally to have resulted in genome size expansions, however, degenerative processes must be at the very least as widespread as horizontal gene transfer. The basic principles of gene degradation and elimination that are being explored in Rickettsia are likely to be of major importance for our understanding of how microbial genomes evolve.
Place, publisher, year, edition, pages
1999. Vol. 9, no 6, 664-671 p.
IdentifiersURN: urn:nbn:se:uu:diva-85234DOI: 10.1016/S0959-437X(99)00024-6OAI: oai:DiVA.org:uu-85234DiVA: diva2:113142
Addresses: Andersson JO, Uppsala Univ, Dept Mol Evolut, Biomed Ctr, Box 590, S-75124 Uppsala, Sweden. Uppsala Univ, Dept Mol Evolut, Biomed Ctr, S-75124 Uppsala, Sweden.2008-10-172008-10-172014-05-14Bibliographically approved