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Application of Methyl Bisphosphine-Ligated Palladium Complexes for Low Pressure N-C-11-Acetylation of Peptides
Aarhus Univ, Carbon Dioxide Activat Ctr CADIAC, Dept Chem, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark.;Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Molecular Imaging.
Aarhus Univ, Carbon Dioxide Activat Ctr CADIAC, Dept Chem, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark.;Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark..
Aarhus Univ Hosp, Dept Nucl Med, DK-8000 Aarhus, Denmark.;Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark..
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2017 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 56, no 16, p. 4549-4553Article in journal (Refereed) Published
Abstract [en]

A mild and effective method is described for C-11-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. The presented method relies on the use of specific biphosphine palladium-methyl complexes and their high reactivity towards amino-carbonylation of amine groups in the presence [C-11] carbon monoxide. The protocol facilitates the production of native N-C-11-acetylated peptides, without any structural modifications and has been applied to a selection of bioactive peptides.

Place, publisher, year, edition, pages
2017. Vol. 56, no 16, p. 4549-4553
Keywords [en]
C-11-labeling, carbonylation, palladium, peptides
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-320628DOI: 10.1002/anie.201700446ISI: 000398154000026PubMedID: 28301077OAI: oai:DiVA.org:uu-320628DiVA, id: diva2:1131515
Funder
Danish National Research Foundation, DNRF118
Note

De 2 sista författarna delar sistaförfattarskapet.

Available from: 2017-08-14 Created: 2017-08-14 Last updated: 2017-08-14Bibliographically approved

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Nordeman, PatrikAntoni, Gunnar

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