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ProQ-dependent phenotypes in Escherichia coli and Salmonella Typhimurium
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2017 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

RNA-binding proteins (RBPs) regulate gene expression at the posttranscriptional

level by interacting with mRNAs and sRNAs. Recently,

ProQ has been discovered to be a global RBP with extensive RNA

targets in

Escherichia coli and Salmonella enterica. However, many

aspects of the function of ProQ, including mechanisms of RNA-binding,

regulated pathways, and ProQ-dependent phenotypes are yet to be

understood. In this study, it is shown that ProQ can affect both persister

cell

􀀀formation and motility. A proQ deletion reduces the number of

persister cells independent of both SOS-response and the persisterrelated

type I toxin/antitoxin system

tisB/istR-1. Furthermore, ProQ

overexpression also reduces persister cell formation, indicating an

intricate regulation by ProQ on persister-related pathways. Finally,

it is confirmed that deletion of

proQ leads to down-regulation of

motility-related genes.

Place, publisher, year, edition, pages
2017.
Series
UPTEC X ; 17 021
National Category
Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-328113OAI: oai:DiVA.org:uu-328113DiVA, id: diva2:1134002
Educational program
Molecular Biotechnology Engineering Programme
Supervisors
Examiners
Available from: 2017-08-22 Created: 2017-08-17 Last updated: 2017-08-22Bibliographically approved

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