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Effect of 6OHDA-induced dopaminergic neuron loss on level of astakine 1 cytokine in crayfish brain and blood cells
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2017 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Prokineticin 2 has been recently discovered to be up regulated in the mice having the Parkinson's disease. The homologue protein of prokineticin 2 in the crayfish, named astatine 1, has been reported to be highly expressed in crayfish blood cells and have very similar functions with the prokineticin 2. However, the role of astakine 1 in the Parkinson's disease has never been researched. Therefore, in this study 6OHDA which is a compound widely used to induce Parkinson’s disease model organisms such as mice and rats was injected into crayfish. After injection, levels of astakine 1 in crayfish brain and blood cells were examined by the western blot. In addition, the number of blood cells was determined and movement of crayfish was observed.

Place, publisher, year, edition, pages
2017. , 13 p.
Keyword [en]
astakine 1, crayfish, dopaminergic neuron, Parkinson disease, 6OHDA
National Category
Behavioral Sciences Biology
Identifiers
URN: urn:nbn:se:uu:diva-328559OAI: oai:DiVA.org:uu-328559DiVA: diva2:1136230
Educational program
Bachelor Programme in Biology / Molecular Biology
Supervisors
Examiners
Available from: 2017-08-31 Created: 2017-08-26 Last updated: 2017-08-31Bibliographically approved

Open Access in DiVA

The full text will be freely available from 2018-01-31 04:42
Available from 2018-01-31 04:42

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