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Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Vestre Viken Hosp Trust, Baerum Hosp, Dept Med Res, Rud, Norway..
Univ Groningen, Dept Cardiol, Univ Med Ctr Groningen, Groningen, Netherlands..
Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Helmholtz Zentrum Munchen German Res Ctr Environm, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Munich, Germany..
NHLBI, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA..
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2017 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 49, no 6, 946-+ p.Article in journal (Refereed) Published
Abstract [en]

Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death(1,2). Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups(3-7). To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery(8).

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 49, no 6, 946-+ p.
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Genetics
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URN: urn:nbn:se:uu:diva-327137DOI: 10.1038/ng.3843ISI: 000402062300020PubMedID: 28416818OAI: oai:DiVA.org:uu-327137DiVA: diva2:1136591
Available from: 2017-08-28 Created: 2017-08-28 Last updated: 2017-08-28Bibliographically approved

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Gustafsson, StefanLind, LarsLannfelt, LarsIngelsson, Erik

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