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A novel strategy to enhance interfacial adhesion infiber-reinforced calcium phosphate cement
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. Universitat Politècnica de Cataluny; Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, Spain . (Materials in Medicine)ORCID iD: 0000-0001-7648-9250
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. (MST/EMBLA)ORCID iD: 0000-0001-7462-4236
Universitat Politècnica de Catalunya; Barcelona Research Center in Multiscale Science and Engineering. (Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)ORCID iD: 0000-0001-6663-6536
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2017 (English)In: Journal of The Mechanical Behavior of Biomedical Materials, ISSN 1751-6161, E-ISSN 1878-0180, Vol. 75, 495-503 p.Article in journal (Refereed) Published
Abstract [en]

Calcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor toughness limits their use to non-load-bearing applications. Reinforcement through introduction of fibers and yarns has been evaluated in various studies but always resulted in a decrease in elastic modulus or bending strength when compared to the CPC matrix. The aim of the present work was to improve the interfacial adhesion between fibers and matrix to obtain tougher biocompatible fiber-reinforced calcium phosphate cements (FRCPCs). This was done by adding a polymer solution to the matrix, with chemical affinity to the reinforcing chitosan fibers, namely trimethyl chitosan (TMC). The improved wettability and chemical affinity of the chitosan fibers with the TMC in the liquid phase led to an enhancement of the interfacial adhesion. This resulted in an increase of the work of fracture (several hundred-fold increase), while the elastic modulus and bending strength were maintained similar to the materials without additives. Additionally the TMC-modified CPCs showed suitable biocompatibility with an osteoblastic cell line.

Place, publisher, year, edition, pages
2017. Vol. 75, 495-503 p.
Keyword [en]
Calcium phosphate cement; Chitosan; Fiber reinforced; Interfacial adhesion; Toughness; Work of fracture
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-328681DOI: 10.1016/j.jmbbm.2017.08.017OAI: oai:DiVA.org:uu-328681DiVA: diva2:1136859
Available from: 2017-08-29 Created: 2017-08-29 Last updated: 2017-08-29Bibliographically approved

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The full text will be freely available from 2019-08-16 16:31
Available from 2019-08-16 16:31

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Gallinetti, SaraMestres, GemmaPersson, Cecilia

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