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Retinoid use during pregnancy and lactation in Finland: analysis of Teratology Information Centre data
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2017 (English)Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Introduction: Retinoids are a group of substances containing vitamin A and its natural and synthetic derivatives. Retinoids are important during embryonic development and they regulate many physiological processes. Embryonal exposure to retinoid medications can cause a characteristic pattern of malformations, with a relative risk of 25 for major malformations. Retinoids are a frequently used group of medications in Finland. In 2015, there were almost 16 000 patients who received systemic retinoids for acne. Because of the teratogenicity of retinoids, pregnancy prevention programs have been established globally to prevent retinoid exposure during pregnancy. In Finland, the prescribing restrictions were updated in 2005. The purpose of this study was to assess the frequency of retinoid use during pregnancy and lactation in Finland, and to study the number of retinoid exposures during pregnancy.

Material and methods: All calls recorded in the Helsinki Teratology Information Service database during June 1st 2006 to December 31st 2016 concerning retinoids were analyzed individually to confirm the exposure and relevance.

Results: In total, 368 inquiries concerned synthetic retinoids, 33 of these concerning retinoid exposures during the first trimester of pregnancy or the wash-out period. Exposures during the first trimester or the wash-out period occurred each year during the study period.

Conclusions: Despite an established pregnancy prevention program, exposures to synthetic retinoids during pregnancy still occur and the number of annual exposures has remained stable and has not decreased. These exposures are potentially avoidable, and more strict measures to prevent inadvertent exposure are needed. These should include more strict policies in prescribing, and increasing awareness in   health care professionals as well as in patients. 

Place, publisher, year, edition, pages
2017.
Keyword [en]
Retinoid, Pregnancy, Teratology, Teratology Information Service
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-328741OAI: oai:DiVA.org:uu-328741DiVA: diva2:1137161
External cooperation
Teratologisk Information, Helsingfors och Nylands Sjukvårdsdistrikt, Finland
Educational program
Master Programme in Drug Management
Presentation
2017-06-02, BMC, Uppsala Universitet, Uppsala, 12:00 (English)
Supervisors
Examiners
Available from: 2017-09-05 Created: 2017-08-30 Last updated: 2017-09-05Bibliographically approved

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CiteExportLink to record
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Citation style
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