uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Frequency and impact of hospital admissions due to anticoagulant-related bleeding: a cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences, Division of Pharmacokinetics and Drug Therapy.
2017 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Introduction: Anticoagulants used in the community have an important role as they may be life-saving in patients with, or at risk for, thromboembolic conditions. However, adverse effects (AEs) such as bleeding can also potentially be life-threatening. With a growing elderly population, use of these medications increases, therefore it is important to identify patients who require closer attention to minimise the incidence and impact of AEs.

Aim:  To determine the frequency and impact of admissions to a tertiary care hospital through the emergency department with bleeding associated with over-anticoagulation.

Materials and Methods:  A retrospective cohort study was conducted at Alfred Health. Patients were identified using anticoagulant-bleeding related diagnostic codes (ICD-10 AM: D68.3; Y44.2; Y44.3). Patients discharged between July 2015-June 2016 with an anticoagulant-bleed diagnosis and minimum one-night hospital admission were included.

Results:  From the 220 patient episodes identified through coding, 81 satisfied the inclusion criteria. The median age was 79 (IQR 70-85) and 49% had major bleeds. Most patients (80%) were admitted on warfarin and managed by withholding anticoagulants and administering reversal agents (97%). Almost 20% required surgery, and ten patients died. Length of stay was approximately 6 days, with a median total episode cost of $8,600.

Conclusions:  These findings identify the current burden for patients at risk of having a bleed due to anticoagulation. With the recent introduction of an Anticoagulation Stewardship Program at Alfred Health, improvements in the way the hospital provides care and follow-up may reduce the incidence of anticoagulant-related bleeding, as well as associated morbidity and mortality.

Place, publisher, year, edition, pages
2017. , 40 p.
Keyword [en]
anticoagulants, bleeding, haemorrhage, australia
Keyword [sv]
antikoagulantia, blödning, Australien
National Category
Social and Clinical Pharmacy
Identifiers
URN: urn:nbn:se:uu:diva-329076OAI: oai:DiVA.org:uu-329076DiVA: diva2:1139443
External cooperation
Alfred Health, Pharmacy Department
Subject / course
Pharmacotherapy
Educational program
Master of Science Programme in Pharmacy
Supervisors
Examiners
Available from: 2017-09-08 Created: 2017-09-07 Last updated: 2017-09-08Bibliographically approved

Open Access in DiVA

No full text

By organisation
Division of Pharmacokinetics and Drug Therapy
Social and Clinical Pharmacy

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 108 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf