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Investigation of endoderm marker-genes during gastrulation and gut-development in the velvet worm Euperipatoides kanangrensis
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.ORCID iD: 0000-0001-9007-4369
2017 (English)In: Developmental Biology, ISSN 0012-1606, E-ISSN 1095-564X, Vol. 427, no 1, 155-164 p.Article in journal (Refereed) Published
Abstract [en]

The ancestral state of animal gastrulation and its bearing for our understanding of bilaterian evolution still is one of the most controversially discussed topics in the field of evolutionary and developmental biology. One hypothesis, the so-called amphistomy scenario, suggests the presence of a slit-like blastopore in the last common ancestor of Bilateria. Onychophoran ontogeny at least superficially appears to support this scenario since a ventral groove clearly forms during gastrulation. The origin and nature of this groove, however, is another matter of ongoing controversy; i.e. the question of whether this structure actually represents the blastopore, or at least part of it. Recent research using genetic markers argued against the furrow representing a blastoporal structure. Here we investigate the origin of endoderm, which usually originates from the blastopore. We find conserved expression patterns of the endoderm- and gut-marker genes GATA456, GATA123, Hnf4 and fkh during gut development, and discuss the formation of the onychophoran gut in comparison with that in a range of arthropods. Despite expression of endodermal markers in and around the furrow we do not find convincing evidence that the furrow may be part of the blastopore, and thus we suggest that onychophoran development does not yield support for the amphistomy scenario.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2017. Vol. 427, no 1, 155-164 p.
Keyword [en]
Amphistomy, Onychophoran development, Blastopore, Endoderm, Gut development, Bilaterian ancestor
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-328981DOI: 10.1016/j.ydbio.2017.04.014ISI: 000404089200015PubMedID: 28465040OAI: oai:DiVA.org:uu-328981DiVA: diva2:1139642
Funder
Swedish Research Council, 621-2011-4703The Royal Swedish Academy of Sciences
Available from: 2017-09-08 Created: 2017-09-08 Last updated: 2017-09-08Bibliographically approved

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Janssen, RalfBudd, Graham

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