uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effects of dabigatran according to age in atrial fibrillation
McMaster Univ, Hamilton, ON, Canada.;Hamilton Hlth Sci, Populat Hlth Res Inst, Gen Hosp 237 Barton St East, Hamilton, ON L8L 2X2, Canada.;Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands..
McMaster Univ, Hamilton, ON, Canada.;Hamilton Hlth Sci, Populat Hlth Res Inst, Gen Hosp 237 Barton St East, Hamilton, ON L8L 2X2, Canada..
McMaster Univ, Hamilton, ON, Canada.;Hamilton Hlth Sci, Populat Hlth Res Inst, Gen Hosp 237 Barton St East, Hamilton, ON L8L 2X2, Canada.;Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Show others and affiliations
2017 (English)In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 103, no 13, 1015-1023 p.Article in journal (Refereed) Published
Abstract [en]

Objective: The prevalence of atrial fibrillation (AF) and the risk of stroke and bleeding vary according to age. To estimate effects of dabigatran, compared with warfarin, on stroke, bleeding and mortality in patients with AF in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial according to age, we analysed treatment effects using age as a continuous variable and using age categories.

Methods: RE-LY included 10 855 (59.9%) patients aged <75 years, 4231 patients (23.4%) aged 75-79 years, 2305 (12.7%) aged 80-84 years and 722 (4.0%) aged >= 85 years at baseline.

Results: Benefits of dabigatran versus warfarin regarding stroke (HR range 0.63 (95% CI 0.46 to 0.86) to 0.70 (0.31 to 1.57) for dabigatran 150 mg twice daily), HR range 0.52 (0.21 to 1.29) to 1.08 (0.73 to 1.60) for dabigatran 110 mg twice daily) and intracranial bleeding were maintained across all age groups (interaction p values all not significant). There was a highly significant interaction (p value interaction <0.001) between age and treatment for extracranial major bleeding, with lower rates with both doses of dabigatran compared with warfarin in younger patients (HR 0.78 (0.62 to 0.97) for 150 mg twice daily, HR 0.72 (0.57 to 0.90) for 110 mg twice daily) but similar (HR 1.50 (1.03 to 2.18) for 110 mg twice daily) or higher rates (HR 1.68 (1.18 to 2.41) for 150 mg twice daily) in older patients (>= 80 years).

Conclusion: Effects of dabigatran compared with warfarin on stroke prevention and intracranial bleeding are consistent across all age groups. Effects of dabigatran on extracranial major bleeding are age dependent, supporting selection of dabigatran 110 mg twice daily for elderly patients (age >= 80 years).

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2017. Vol. 103, no 13, 1015-1023 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-328972DOI: 10.1136/heartjnl-2016-310358ISI: 000403232200011PubMedID: 28213368OAI: oai:DiVA.org:uu-328972DiVA: diva2:1140562
Available from: 2017-09-12 Created: 2017-09-12 Last updated: 2017-09-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Wallentin, LarsOldgren, Jonas

Search in DiVA

By author/editor
Wallentin, LarsOldgren, Jonas
By organisation
UCR-Uppsala Clinical Research CenterDepartment of Medical Sciences
In the same journal
Heart
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 44 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf