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Non-lamellar lipid assembly at interfaces: controlling layer structure by responsive nanogel particles
Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden.;Lund Univ, NanoLund, POB 118, S-22100 Lund, Sweden..
Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden..
Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden..
Univ Florence, Dept Chem, Florence, Italy.;CSGI, Florence, Italy..
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2017 (English)In: Interface Focus, ISSN 2042-8898, E-ISSN 2042-8901, Vol. 7, no 4, 20160150Article in journal (Refereed) Published
Abstract [en]

Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing three-dimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid non-lamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid films formed reflect those in the bulk. Most notably, mixed lipid layers, which are composed of glycerol monooleate and diglycerol monooleate with poly(N-isopropylacrylamide) nanogels, can form films of reverse cubic phases that are capable of responding to temperature stimulus. Owing to the presence of the nanogel particles, changing the temperature not only regulates the hydration of the cubic phase lipid films, but also the lateral organization of the lipid domains within the lipid self-assembled film. This opens up the possibility for new nanostructured materials based on lipid-polymer responsive layers.

Place, publisher, year, edition, pages
ROYAL SOC , 2017. Vol. 7, no 4, 20160150
Keyword [en]
responsive lipid layers, nanogel, microgel, lipid non-lamellar liquid crystalline, cubic bicontinuous phases, neutron reflectivity
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-328956DOI: 10.1098/rsfs.2016.0150ISI: 000403686000012PubMedID: 28630677OAI: oai:DiVA.org:uu-328956DiVA: diva2:1140835
Funder
Swedish Research Council, 2015-05988EU, FP7, Seventh Framework Programme, 606713Knut and Alice Wallenberg Foundation
Available from: 2017-09-13 Created: 2017-09-13 Last updated: 2017-09-13Bibliographically approved

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Pálsson, Gunnar K.George, Sebastian

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