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Evolution of antibiotic resistance without antibiotic exposure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (Joakim Näsvall)ORCID iD: 0000-0002-6831-3105
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
(Swedish)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596Article in journal (Refereed) Epub ahead of print
Abstract [en]

Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can co-select for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evolution by generating a pool of resistance mutations that selection could act on to enrich resistant mutants when antibiotic exposure occurs.

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Microbiology
Research subject
Microbiology
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URN: urn:nbn:se:uu:diva-329358DOI: 10.1128/AAC.01495-17OAI: oai:DiVA.org:uu-329358DiVA: diva2:1141004
Available from: 2017-09-13 Created: 2017-09-13 Last updated: 2017-09-13

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