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Targeting HSP90 with the inhibitor AT13387 in tumour cells
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2017 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The use of HSP90 inhibitors as drugs for cancer has been under

research for a long time. The synthetic made inhibitor, AT13387 is

one of them. AT13387 is in clinical trials and is looking promising

as a therapeutic drug for cancer. However, since cancer cells can be

radioresistant researchers are focusing on finding radiosensitizing

agents. Previous publications show that AT13387 might be one of these

radiosensitizing agents. This study is investigating whether AT13387

possesses radiosensitizing effects on tumour cells and what the

mechanisms behind this radiosensitizing effect can be. Results from

this study are showing trends of radiosensitizing effects on tumour

cells although more investigation is needed. The study reveals upand

down regulation of several important proteins in tumour cells

after treatment with the drug and irradiation. It also demonstrates

the effect the treatment has on cell viability and migration. This

study supports the fact that AT13387 is a promising therapeutic drug

against cancer and promotes more investigation in the co-treatment of

AT13387 and irradiation.

Place, publisher, year, edition, pages
2017.
Series
UPTEC X ; 17 023
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-329743OAI: oai:DiVA.org:uu-329743DiVA, id: diva2:1142773
Educational program
Molecular Biotechnology Engineering Programme
Supervisors
Examiners
Available from: 2017-09-25 Created: 2017-09-20 Last updated: 2017-09-25Bibliographically approved

Open Access in DiVA

The full text will be freely available from 2019-01-02 10:25
Available from 2019-01-02 10:25

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