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Micrometre-sized magnesium whitlockite crystals in micropetrosis of bisphosphonate-exposed human alveolar bone
Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Department of Materials Science and Engineering, McMaster University, Hamilton .ORCID iD: 0000-0002-9876-0467
School of Biomedical Engineering, McMaster University, Hamilton.
Department of Materials Science and Engineering, McMaster University, Hamilton.
Department of Biomaterials, Sahlgrenska Academy at University, Department of Oral and Maxillofacial Surgery, Sö dra Älvsborg Hospital of Gothenburg, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therap.
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2017 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 17, no 10, 6210-6216 p.Article in journal (Refereed) Published
Abstract [en]

Osteocytes are contained within spaces called lacunae and play a central role in bone remodelling. Administered frequently to prevent osteoporotic fractures, antiresorptive agents such as bisphosphonates suppress osteocyte apoptosis and may be localized within osteocyte lacunae. Bisphosphonates also reduce osteoclast viability and thereby hinder the repair of damaged tissue. Osteocyte lacunae contribute to toughening mechanisms. Following osteocyte apoptosis, the lacunar space undergoes mineralization, termed “micropetrosis”. Hypermineralized lacunae are believed to increase bone fragility. Using nanoanalytical electron microscopy with complementary spectroscopic and crystallographic experiments, postapoptotic mineralization of osteocyte lacunae in bisphosphonate-exposed human bone was investigated. We report an unprecedented presence of ∼80 nm to ∼3 μm wide, distinctly faceted, magnesium whitlockite [Ca18Mg2(HPO4)2(PO4)12] crystals and consequently altered local nanomechanical properties. These findings have broad implications on the role of therapeutic agents in driving biomineralization and shed new insights into a possible relationship between bisphosphonate exposure, availability of intracellular magnesium, and pathological calcification inside lacunae.

Place, publisher, year, edition, pages
2017. Vol. 17, no 10, 6210-6216 p.
Keyword [en]
Osteocyte lacuna, mineralization, micropetrosis, magnesium, whitlockite, bisphosphonates
National Category
Biomaterials Science Engineering and Technology
Research subject
Engineering Science with specialization in Materials Science
Identifiers
URN: urn:nbn:se:uu:diva-330185DOI: 10.1021/acs.nanolett.7b02888OAI: oai:DiVA.org:uu-330185DiVA: diva2:1144897
Funder
Swedish Research Council, K2015-52X-09495-28-4)Region Västra Götaland
Available from: 2017-09-27 Created: 2017-09-27 Last updated: 2017-12-08

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