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Interactions of perfluoroalkyl substances with a phospholipid bilayer studied by neutron reflectometry
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics. (Material physics)ORCID iD: 0000-0002-5203-8057
Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU).ORCID iD: 0000-0002-5430-6764
Swedish University of Agricultural Sciences: Uppsala, Sweden.ORCID iD: 0000-0002-8023-0767
Rutherford Appleton Laboratory, Harwell Oxford, Didcot OX11 0QX, United Kingdom.
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2017 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 511, p. 474-481Article in journal (Refereed) Published
Abstract [en]

The interactions between perfluoroalkyl substances (PFASs) and a phospholipid bilayer (1,2-dimyristoyl-sn-glycero-3-phosphocholine) were investigated at the molecular level using neutron reflectometry. Representative PFASs with different chain length and functional groups were selected in this study including: perfluorobutane sulfonate (PFBS), perfluorohexanoate (PFHxA), perfluorohexane sulfonate (PFHxS), perfluorononanoate (PFNA), perfluorooctane sulfonate (PFOS), and perfluorooctane sulfonamide (FOSA). All PFASs were found to interact with the bilayer by incorporation, indicating PFAS ability to accumulate once ingested or taken up by organisms. The interactions were observed to increase with chain length and vary with the functional group as SO2NH2" role="presentation">(FOSA) > SO2O−" role="presentation">(PFOS) > COO(PFNA). The PFAS hydrophobicity, which is strongly correlated with perfluorocarbon chain length, was found to strongly influence the interactions. Longer chain PFASs showed higher tendency to penetrate into the bilayer compared to the short-chain compounds. The incorporated PFASs could for all substances but one (PFNA) be removed from the lipid membrane by gentle rinsing with water (2 mL min−1). Although short-chain PFASs have been suggested to be the potentially less bioaccumulative alternative, we found that in high enough concentrations they can also disturb the bilayer. The roughness and disorder of the bilayer was observed to increase as the concentration of PFASs increased (in particular for the high concentrations of short-chain substances i.e. PFHxA and PFBS), which can be an indication of aggregation of PFASs in the bilayer.

Place, publisher, year, edition, pages
2017. Vol. 511, p. 474-481
National Category
Condensed Matter Physics
Identifiers
URN: urn:nbn:se:uu:diva-330505DOI: 10.1016/j.jcis.2017.09.102ISI: 000417008200053PubMedID: 29073553OAI: oai:DiVA.org:uu-330505DiVA, id: diva2:1146128
Funder
Swedish Research Council, 621-2012-4382Swedish Research Council, 2015-03938
Available from: 2017-10-02 Created: 2017-10-02 Last updated: 2018-03-05Bibliographically approved

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Nouhi, ShirinPálsson, Gunnar K.Hellsing, Maja S.

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