uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP
Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden..
Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden..
Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden..
Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden..
Show others and affiliations
2017 (English)In: Forensic Science International, ISSN 0379-0738, E-ISSN 1872-6283, Vol. 275, 76-82 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: 3-methoxyphencyclidine (3-MeO-PCP) appeared on the illicit drug market in 2011 and is an analogue of phencyclidine, which exhibits anesthetic, analgesic and hallucinogenic properties. In this paper, we report data from a non-fatal intoxication and seven deaths involving 3-MeO-PCP in Sweden during the period March 2014 until June 2016. Case descriptions: The non-fatal intoxication case, a 19-year-old male with drug problems and a medical history of depression, was found awake but tachycardic, hypertensive, tachypnoeic and catatonic at home. After being hospitalized, his condition worsened as he developed a fever and lactic acidosis concomitant with psychomotor agitation and hallucinations. After 22 h of intensive care, the patient had made a complete recovery. During his hospitalization, a total of four blood samples were collected at different time points. The seven autopsy cases, six males and one female, were all in their twenties to thirties with psychiatric problems and/or an ongoing drug abuse. Methods: 3-MeO-PCP was identified with liquid chromatography (LC)/time-of-flight technology and quantified using LC-tandem mass spectrometry. Results: In the clinical case, the concentration of 3-MeO-PCP was 0.14 mu g/g at admission, 0.08 mu g/g 2.5 h after admission, 0.06 mu g/g 5 h after admission and 0.04 mu g/g 17 h after admission. The half-life of 3-MeO-PCP was estimated to 11 h. In the autopsy cases, femoral blood concentrations ranged from 0.05 mu g/g to 0.38 mu g/g. 3-MeO-PCP was the sole finding in the case with the highest concentration and the cause of death was established as intoxication with 3-MeO-PCP. In the remaining six autopsy cases, other medications and drugs of abuse were present as well. Conclusion: Despite being scheduled in January 2015, 3-MeO-PCP continues to be abused in Sweden. Exposure to 3-MeO-PCP may cause severe adverse events and even death, especially if the user does not receive life-supporting treatment.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2017. Vol. 275, 76-82 p.
Keyword [en]
Dissociative drugs, Phencyclidine, 3-MeO-PCP, Intoxication, Postmortem blood concentrations
National Category
Forensic Science
Identifiers
URN: urn:nbn:se:uu:diva-330757DOI: 10.1016/j.forsciint.2017.02.034ISI: 000404011100011PubMedID: 28324770OAI: oai:DiVA.org:uu-330757DiVA: diva2:1146609
Available from: 2017-10-03 Created: 2017-10-03 Last updated: 2017-10-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Nielsen, Elisabet I.Sandler, HåkanRubertsson, Sten

Search in DiVA

By author/editor
Nielsen, Elisabet I.Lennborn, UlricaSandler, HåkanRubertsson, Sten
By organisation
Department of Pharmaceutical BiosciencesAnaesthesiology and Intensive CareForensic Medicine
In the same journal
Forensic Science International
Forensic Science

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 21 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf