uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Conjugation of cyclodextrin to magnetic Fe3O4 nanoparticles via polydopamine coating for drug delivery
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan.
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)ORCID iD: 0000-0002-7356-3002
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.ORCID iD: 0000-0001-9998-0480
Show others and affiliations
2018 (English)In: Progress in organic coatings, ISSN 0300-9440, E-ISSN 1873-331X, Vol. 114, p. 154-161Article in journal (Refereed) Published
Abstract [en]

In this study, a novel magnetic nanocarrier for hydrophobic drugs (β-CD–PDA–MNPs) was fabricated using surface coating of Fe3O4 nanoparticles with polydopamine (PDA) followed by functionalization with 6-thio-β-cyclodextrin (6-thio-β-CD). The obtained magnetic nanoparticles were employed to investigate their interactions with diclofenac (DCF) as a model hydrophobic drug. The resulting β-CD–PDA–MNPs were characterized by various methods including transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and vibrating sample magnetometry (VSM). The newly fabricated magnetic nanocarrier exhibited considerably higher drug loading capacity as compared for its analogue lacking CD ligands. Moreover, the release profile of DCF from β-CD–PDA–MNPs showed a burst release during the initial 8 h followed by the drug sustained release. Facile coating of magnetic nanoparticles with PDA was therefore a robust synthetic procedure for the conversion of the nanoparticles into a drug vehicle.

Place, publisher, year, edition, pages
2018. Vol. 114, p. 154-161
Keyword [en]
Magnetic nanoparticles, β Cyclodextrin, Host-guest interactions, Diclofenac, Drug delivery
National Category
Medical Materials
Identifiers
URN: urn:nbn:se:uu:diva-330899DOI: 10.1016/j.porgcoat.2017.10.007ISI: 000417661100017OAI: oai:DiVA.org:uu-330899DiVA, id: diva2:1147510
Available from: 2017-10-06 Created: 2017-10-06 Last updated: 2018-02-02Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Oroujeni, MaryamXia, WeiJönsson, PetraOssipov, Dmitri A.

Search in DiVA

By author/editor
Oroujeni, MaryamXia, WeiJönsson, PetraOssipov, Dmitri A.
By organisation
Applied Materials SciencesMaterials PhysicsPolymer Chemistry
In the same journal
Progress in organic coatings
Medical Materials

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 310 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf