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Personality as an intermediate phenotype for genetic dissection of alcohol use disorder.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.ORCID iD: 0000-0002-8853-2508
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2018 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 125, no 1, p. 107-130Article, review/survey (Refereed) Published
Abstract [en]

Genetic and environmental interactive influences on predisposition to develop alcohol use disorder (AUD) account for the high heterogeneity among AUD patients and make research on the risk and resiliency factors complicated. Several attempts have been made to identify the genetic basis of AUD; however, only few genetic polymorphisms have consistently been associated with AUD. Intermediate phenotypes are expected to be in-between proxies of basic neuronal biological processes and nosological symptoms of AUD. Personality is likely to be a top candidate intermediate phenotype for the dissection of the genetic underpinnings of different subtypes of AUD. To date, 38 studies have investigated personality traits, commonly assessed by the Cloninger's Tridimensional Personality Questionnaire (TPQ) or Temperament and Character Inventory (TCI), in relation to polymorphisms of candidate genes of neurotransmitter systems in alcohol-dependent patients. Particular attention has been given to the functional polymorphism of the serotonin transporter gene (5-HTTLPR), however, leading to contradictory results, whereas results with polymorphisms in other candidate monoaminergic genes (e.g., tryptophan hydroxylase, serotonin receptors, monoamine oxidases, dopamine receptors and transporter) are sparse. Only one genome-wide association study has been performed so far and identified the ABLIM1 gene of relevance for novelty seeking, harm avoidance and reward dependence in alcohol-dependent patients. Studies investigating genetic factors together with personality could help to define more homogenous subgroups of AUD patients and facilitate treatment strategies. This review also urges the scientific community to combine genetic data with psychobiological and environmental data to further dissect the link between personality and AUD.

Place, publisher, year, edition, pages
2018. Vol. 125, no 1, p. 107-130
Keywords [en]
AUD, Alcohol, Gene, Personality, Serotonin
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:uu:diva-330920DOI: 10.1007/s00702-016-1672-9ISI: 000419460500013PubMedID: 28054193OAI: oai:DiVA.org:uu-330920DiVA, id: diva2:1147638
Funder
Lars Hierta Memorial FoundationForte, Swedish Research Council for Health, Working Life and WelfareSwedish Research Council, VR: 2015-00495EU, FP7, Seventh Framework Programme, INCA 600398Available from: 2017-10-06 Created: 2017-10-06 Last updated: 2018-05-31Bibliographically approved

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Oreland, LarsNillson, Kent W.Comasco, Erika

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Neuro-psycho-pharmacologyDepartment of NeuroscienceCentre for Clinical Research, County of Västmanland
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