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Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Univ Gothenburg, Dept Psychol, Gothenburg, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
2017 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 222, no 1, article id e12892Article in journal (Refereed) Published
Abstract [en]

Several explanations for the diverse results in research on foetal alcohol spectrum disorders or alcohol-related neurodevelopmental disorder might be at hand: timing, amount and patterns of alcohol exposure, as well as complex epigenetic responses. The genetic background of the offspring and its interaction with other prenatal and post-natal environmental cues are likely also of importance. In the present report, key findings about the possible effects of low and moderate doses of maternal alcohol intake on the neuropsychological development of the offspring are reviewed and plausible mechanisms discussed. Special focus is put on the serotonergic system within developmental and gene-environment frameworks. The review also suggests guidelines for future studies and also summarizes some of to-be-answered questions of relevance to clinical practice. Contradictory findings and paucity of studies on the effects of exposure to low alcohol levels during foetal life for the offspring's neuropsychological development call for large prospective studies, as well as for studies including neuroimaging and multi-omics analyses to dissect the neurobiological underpinnings of alcohol exposure-related phenotypes and to identify biomarkers. Finally, it remains to be investigated whether any safe threshold of alcohol drinking during pregnancy can be identified.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 222, no 1, article id e12892
Keywords [en]
alcohol, development, epigenetics, gene, pregnancy, prenatal
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-330918DOI: 10.1111/apha.12892ISI: 000419864000007PubMedID: 28470828OAI: oai:DiVA.org:uu-330918DiVA, id: diva2:1147639
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2011-0627Swedish Research Council, 2009-3640 2015-00495AFA Insurance, SA-07:03EU, European Research Council, INCA 600398Available from: 2017-10-06 Created: 2017-10-06 Last updated: 2018-05-31Bibliographically approved

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Comasco, ErikaEriksson, Ulf J.Oreland, Lars

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