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Endostatin: a promising biomarker in the cardiovascular continuum?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.ORCID iD: 0000-0003-3161-0402
2017 (English)In: Biomarkers in Medicine, ISSN 1752-0363, E-ISSN 1752-0371, Vol. 11, no 10, p. 905-916Article, review/survey (Refereed) Published
Abstract [en]

The current review article aims to provide an up-to-date summary of previous studies in humans that have reported the association between circulating endostatin levels and different cardiovascular phenotypes. We also aim to provide suggestions for future directions of future research evaluating endostatin as a clinically relevant cardiovascular biomarker. With a few exceptions, higher circulating levels of endostatin seem to reflect vascular and myocardial damage, and a worsened prognosis for cardiovascular events or mortality in individuals with hypertension, diabetes, kidney disease, cardiovascular disease, as well as in the general population. Circulating endostatin seems to be a promising biomarker for cardiovascular pathology, but there is not enough evidence to date to support the use of endostatin measurements in clinical practice.

Place, publisher, year, edition, pages
2017. Vol. 11, no 10, p. 905-916
Keywords [en]
angiogenesis, atherosclerosis, biomarker, chronic kidney disease, collagen XVIII, epidemiological studies, extracellular matrix, glomerular filtration rate, heart failure, mortality
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-330937DOI: 10.2217/bmm-2017-0025ISI: 000416422600009PubMedID: 28976780OAI: oai:DiVA.org:uu-330937DiVA, id: diva2:1147698
Funder
Swedish Research CouncilSwedish Heart Lung FoundationEU, Horizon 2020, 634869Marianne and Marcus Wallenberg FoundationAvailable from: 2017-10-07 Created: 2017-10-07 Last updated: 2018-03-12Bibliographically approved

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Carlsson, Axel CLarsson, Anders

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