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Middle Ear Function and Pathophysiology in Andean Children Living at High Altitudes
Harvard Univ, Harvard Med Sch, Dept Neurol, Biol Labs, 16 Divin Ave, Cambridge, MA 02138 USA.;Massachusetts Gen Hosp, Dept Neurophysiol, Boston, MA 02114 USA..
Harvard Univ, Dept Otolaryngol, Audiol Clin, Hlth Serv, 16 Divin Ave, Cambridge, MA 02138 USA..
Univ San Francisco Quito, Escuela Salud Publ, Colegio Ciencias Salud, Quito, Ecuador.;Univ San Francisco Quito, Galapagos Inst Arts & Sci GAIAS, Quito, Ecuador..
Harvard Univ, Harvard Biol Labs, 16 Divin Ave, Cambridge, MA 02138 USA..
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2017 (English)In: High Altitude Medicine & Biology, ISSN 1527-0297, E-ISSN 1557-8682, Vol. 18, no 2, 163-170 p.Article in journal (Refereed) Published
Abstract [en]

The extent of altitude-related middle ear disorders in children native to high altitudes is unclear. This study examined middle ear pathophysiology in two groups of children living in high-altitude Ecuadorian Andean communities by investigating middle ear pressure (MEP), tympanic membrane compliance (TMC), and ear canal volume (ECV) using tympanometry, and by otological examination. Altitude I Group lived at 2850m, and Altitude II Group resided at around 4000m. The two high-altitude groups were compared with a reference group of children residing at sea level. Mean MEP was -3.6daPa (SD: 39.2), 3.5daPa (SD: 28.7), and 1.3daPa (SD: 13.6) for Altitude I Group, Altitude II Group, and the Sea Level Group, respectively. The MEP was not significantly different among the three groups. Mean TMC was 0.63cm3 (SD: 0.51), 0.60cm3 (SD: 0.43), and 0.60cm3 (SD: 0.24) for Altitude I Group, Altitude II Group, and the Sea Level Group, respectively. The TMC was not significantly different among the three groups. Mean ECV was 1.1 (SD: 0.26), 1.2 (SD: 0.26), and 1.0 (SD: 0.23) for Altitude I Group, Altitude II Group, and the Sea Level Group, respectively. The difference in ECV between Altitude I Group and Altitude II Group was significant (p=0.043), as was the difference between Altitude II Group and the Sea Level Group (p=0.001). ECV did not differ significantly between Altitude I Group and the Sea Level Group. Otological examination revealed a low incidence of ear canal and middle ear pathology. In conclusion, tympanometric and otological findings did not reveal a high incidence of middle ear pathophysiology in children living at altitudes as high as around 4000m.

Place, publisher, year, edition, pages
2017. Vol. 18, no 2, 163-170 p.
Keyword [en]
altitude, Andean, hypoxia, impedance, middle ear disorders, tympanometry
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:uu:diva-329702DOI: 10.1089/ham.2016.0160ISI: 000403937500010PubMedID: 28530447OAI: oai:DiVA.org:uu-329702DiVA: diva2:1148046
Available from: 2017-10-09 Created: 2017-10-09 Last updated: 2017-10-09Bibliographically approved

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