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Single Nucleotide Polymorphism and Cancer Risk, Tumour Recurrence, or Survival of Head and Neck Cancer Patients
Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden;Ryhov Hosp, Div Med Diagnost, Forsjorningsvagen 8, SE-55185 Jonkoping, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. (Magnus Lindskog)
Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden;Ryhov Hosp, Div Med Diagnost, Forsjorningsvagen 8, SE-55185 Jonkoping, Sweden.
Ryhov Hosp, Dept Oncol, Jonkoping, Sweden.
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2017 (English)In: Oncology, ISSN 0030-2414, E-ISSN 1423-0232, Vol. 92, p. 161-169Article in journal (Refereed) Published
Abstract [en]

Objective: This paper aims at studying the influence of single-nucleotide polymorphisms (SNPs) on cancer risk, tumor recurrence, and survival in head and neck (H&N) cancer patients. Methods: A total of 45 SNPs in 41 genes were investigated. A total of 174 Caucasian H&N cancer patients and 245 healthy blood donors were enrolled in the study. Results: Ten SNPs were associated with H&N cancer risk, but the identified SNPs differed among males and females. Some of the SNPs were related to immune response genes. The immune response gene SNPs were also related to survival. In particular, we noted that the tumor necrosis factor alpha (TNFα) rs1800629 could have an influence on cancer risk, tumor recurrence as well as survival. Conclusion: Genetic variation of the TNFα rs1800629 might be useful as a biomarker in clinical decision-making since it was found to be related to cancer risk, tumor recurrence, and survival of H&N cancer patients.

Place, publisher, year, edition, pages
2017. Vol. 92, p. 161-169
Keywords [en]
Tumor recurrence, Survival time, Single-nucleotide polymorphisms, Head and neck cancer
National Category
Cancer and Oncology Otorhinolaryngology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:uu:diva-331352DOI: 10.1159/000452278ISI: 000395366800005PubMedID: 27997918OAI: oai:DiVA.org:uu-331352DiVA, id: diva2:1149020
Note

L. Cederblad, B.-Å. Andersson, and M. Olin contributed equally to this work.

Available from: 2017-10-13 Created: 2017-10-13 Last updated: 2018-09-14Bibliographically approved
In thesis
1. Aspects on Head and neck Cancer with special reference to Salivary Gland Tumours and Single Nucleotide Polymorphism
Open this publication in new window or tab >>Aspects on Head and neck Cancer with special reference to Salivary Gland Tumours and Single Nucleotide Polymorphism
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A thesis on Head and neck cancer focusing on dose planning, salivary gland carcinoma and Single nucleotide polymorphism.

For dose planning PET/CT (Positron emissions tomography/computed tomography) with tracer gave more precise information in comparison dose planning with CT. More primary tumours and metastases were found with the acetate tracer than with glucose tracer. Acetate PET/CT also showed larger volume of tumours attributed to lipid metabolism.

In a retrospective study salivary gland cancer 5-year overall survival (OS) was 53 %. Salivary gland carcinoma consists of many histopathological groups, the two largest groups being mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ASCC). For ACC, having the best 5-year OS, it was 70 percent. Facial palsy, advanced stage disease, lymph node metastases worsened prognosis. ACC and polymorphous low grade carcinoma (PLGA) expressed c-myc and cyclin D1 to a larger extent than MEC.

In squamous cell carcinoma of the head and neck we examined the occurrence of Single Nucleotide polymorphism, SNP. We found that the SNPs in male and female patients differed from each other. In male patients the SNPs were associated with immune response while in female patients the association was to SNPs concerning inflammation. This means that different pathways were engaged in cancer development for men and women. We also found that the SNPs in patients were different from those expressed in the healthy controls.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2017. p. 47
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1390
Keywords
salivary gland carcinoma, adenoid cystic, mucoepidermoid, polymorphous low-grade carinoma, c-myc, cyclin D1, perineural
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-332192 (URN)978-91-513-0130-3 (ISBN)
Public defence
2017-12-14, Skoogsalen, ingång 78/79 pl 1, Akademiska sjukhuset, Uppsala, 09:00 (Swedish)
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Supervisors
Available from: 2017-11-20 Created: 2017-10-25 Last updated: 2018-03-07

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Cederblad, LenaEngström, Mats

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