uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Pulse-modulated Model of Testosterone Regulation Subject to Exogenous Signals
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control.ORCID iD: 0000-0002-6608-250x
Southwest State Univ, Dept Comp Sci, 50 Years October Str 94, Kursk 305040, Russia..
2016 (English)In: 2016 IEEE 55th Conference On Decision And Control (CDC), New York: IEEE, 2016, 5023-5028 p.Conference paper, Published paper (Refereed)
Abstract [en]

Dynamical behaviors arising due to continuous exogenous signals in a previously developed pulse-modulated mathematical model of non-basal testosterone regulation in the human male are studied. In the context of endocrine regulation, exogenous signals represent e.g. the drugs used in hormone replacement therapies, the effects due to circadian rhythm, and interactions with other endocrine loops of the organism. The model dynamics are hybrid since the hormone metabolism is suitably captured by a continuous description and the control feedback is implemented in a discrete (i.e. event-based) manner by the hypothalamus of the brain. It is demonstrated that the endocrine loop with an exogenous signal entering the continuous part can be equivalently described by proper modifications in the pulse-modulation functions of the autonomous model. This extends the scope of the autonomous pulse-modulated models of endocrine regulation to a broader class of problems, such as therapy optimization, where an exogenous signal is involved. The cases of constant and harmonic exogenous signals are treated in detail and illustrated by bifurcation analysis.

Place, publisher, year, edition, pages
New York: IEEE, 2016. 5023-5028 p.
Series
IEEE Conference on Decision and Control, ISSN 0743-1546
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:uu:diva-331393DOI: 10.1109/CDC.2016.7799037ISI: 000400048105036ISBN: 978-1-5090-1837-6 OAI: oai:DiVA.org:uu-331393DiVA: diva2:1149205
Conference
55th IEEE Conference on Decision and Control (CDC), DEC 12-14, 2016, Las Vegas, NV
Funder
Swedish Research Council, 2015-05256
Available from: 2017-10-13 Created: 2017-10-13 Last updated: 2017-10-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Mattsson, PerMedvedev, Alexander

Search in DiVA

By author/editor
Mattsson, PerMedvedev, Alexander
By organisation
Division of Systems and ControlAutomatic control
Electrical Engineering, Electronic Engineering, Information Engineering

Search outside of DiVA

GoogleGoogle Scholar

doi
isbn
urn-nbn

Altmetric score

doi
isbn
urn-nbn
Total: 11 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf