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Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma.
Lund Univ, Dept Lab Med, Translat Canc Res, Lund, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-6600-9302
Dept Expt Med, Matrix Biol, Lund, Sweden.
Dept Expt Med, Matrix Biol, Lund, Sweden.
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2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 8, e0182973Article in journal (Refereed) Published
Abstract [en]

Tumor barrier function in carcinoma represents a major challenge to treatment and is therefore an attractive target for increasing drug delivery. Variables related to tumor barrier include aberrant blood vessels, high interstitial fluid pressure, and the composition and structure of the extracellular matrix. One of the proteins associated with dense extracellular matrices is fibromodulin, a collagen fibrillogenesis modulator expressed in tumor stroma but scarce in normal loose connective tissues. Here, we investigated the effects of fibromodulin on stroma ECM in a syngeneic murine colon carcinoma model. We show that fibromodulin deficiency decreased collagen fibril thickness but glycosaminoglycan content and composition were unchanged. Furthermore, vascular density, pericyte coverage and macrophage amount were unaffected. Fibromodulin can therefore be a unique effector of dense collagen matrix assembly in tumor stroma and, without affecting other major matrix components or the cellular composition, can function as a main agent in tumor barrier function.

Place, publisher, year, edition, pages
2017. Vol. 12, no 8, e0182973
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-331648DOI: 10.1371/journal.pone.0182973ISI: 000408069300010PubMedID: 28827814OAI: oai:DiVA.org:uu-331648DiVA: diva2:1149601
Funder
Swedish Cancer SocietySwedish Research Council
Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2017-11-23Bibliographically approved

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Kalamajski, SebastianRubin, Kristofer

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