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Y Chromosome Uncovers the Recent Oriental Origin of Modern Stallions
Univ Vet Med Vienna, Inst Anim Breeding & Genet, A-1210 Vienna, Austria..
Univ Vet Med Vienna, Inst Populat Genet, A-1210 Vienna, Austria.;Univ Vet Med Vienna, Inst Parasitol, A-1210 Vienna, Austria..
Univ Vet Med Vienna, Inst Anim Breeding & Genet, A-1210 Vienna, Austria..
Univ Vet Med Vienna, Inst Anim Breeding & Genet, A-1210 Vienna, Austria..
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2017 (English)In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 27, no 13, 2029-2035 p.Article in journal (Refereed) Published
Abstract [en]

The Y chromosome directly reflects male genealogies, but the extremely low Y chromosome sequence diversity in horses has prevented the reconstruction of stallion genealogies [1, 2]. Here, weresolve the first Y chromosomegenealogy of modern horses by screening 1.46 Mb of the male-specific region of the Y chromosome (MSY) in 52 horses from 21 breeds. Based on highly accurate pedigree data, we estimated the de novo mutation rate of the horse MSY and showed that various modern horse Y chromosome lineages split much later than the domestication of the species. Apart from few private northern European haplotypes, all modern horse breeds clustered together in a roughly 700-year-old haplogroup that was transmitted to Europe by the import of Oriental stallions. The Oriental horse group consisted of two major subclades: the Original Arabian lineage and the Turkoman horse lineage. We show that the English Thoroughbred MSY was derived from the Turkoman lineage and that English Thoroughbred sires are largely responsible for the predominance of this haplotype in modern horses.

Place, publisher, year, edition, pages
CELL PRESS , 2017. Vol. 27, no 13, 2029-2035 p.
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Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-331241DOI: 10.1016/j.cub.2017.05.086ISI: 000405114300034PubMedID: 28669755OAI: oai:DiVA.org:uu-331241DiVA: diva2:1150199
Funder
EU, European Research Council
Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-10-18Bibliographically approved

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Rubin, Carl-JohanAndersson, Leif

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