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Successful treatment with placenta-derived decidual stromal cells in a pediatric patient with life-threatening acute gastrointestinal graft-versus-host disease
Karolinska Inst, Dept Clin Intervent & Technol CLINTEC, Stockholm, Sweden.;Childrens Univ Hosp, Dept Womens & Childrens Hlth, Pediat Oncol, Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Childrens Univ Hosp, Dept Womens & Childrens Hlth, Pediat Oncol, Uppsala, Sweden.
Karolinska Univ Hosp, Dept Pathol & Cytol, Stockholm, Sweden..
Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden..
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2017 (English)In: Pediatric Transplantation, ISSN 1397-3142, E-ISSN 1399-3046, Vol. 21, no 5, e12990Article in journal (Refereed) Published
Abstract [en]

Severe aGvHD is a life-threatening complication after allogeneic HSCT. The GI tract is considered to play a key role in aGvHD, where the disease process can start and is one of the major target organs. Here, we present a case of a one-year-old child with a life-threatening GI-aGvHD stage IV, post-HSCT, resistant to steroids and MMF for 4 weeks. He was successfully treated with placenta-derived DSC.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 21, no 5, e12990
Keyword [en]
acute graft-versus-host disease, decidual stromal cells, pediatric allogeneic hematopoietic stem cell transplantation, steroid-refractory gastrointestinal bleedings
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-331217DOI: 10.1111/petr.12990ISI: 000405561700024OAI: oai:DiVA.org:uu-331217DiVA: diva2:1150223
Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-10-18Bibliographically approved

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