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Spark plasma sintering of biodegradable Si3N4 bioceramic with Sr, Mg and Si as sintering additives for spinal fusion
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Material in Medicine)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Material in Medicine)ORCID iD: 0000-0001-9529-650X
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Material in Medicine)ORCID iD: 0000-0002-7356-3002
2018 (English)In: Journal of the European Ceramic Society, ISSN 0955-2219, E-ISSN 1873-619X, Vol. 38, no 4, p. 2110-2119Article in journal (Refereed) Published
Abstract [en]

Silicon nitride (Si3N4) bioceramics with standard sintering additives (Al2O3 and Y2O3) are used in spinal fusion. Alternative Si3N4 bioceramics with biologically beneficial sintering additives could lead to improved osseoin- tegrative properties. The aim of this study is to obtain dense and strong Si3N4 bioceramics by using SrO, MgO and SiO2 as sintering additives, and evaluate the effect of these sintering additives on microstructures and properties of Si3N4 bioceramics. Raw powders with 10 wt% and 18 wt% sintering additives were sintered by spark plasma sintering. Samples sintered at 1750 °C, with an applied pressure of 60 MPa and a holding time of 3 min, showed the highest content of β-Si3N4 (94.9%). The mechanical properties of the developed Si3N4 bio- ceramics are comparable to the mechanical properties of currently used structural Si3N4 ceramics sintered with standard sintering additives (Al2O3 and Y2O3). The highest flexural strength of the developed Si3N4 bioceramics reached 1079 MPa. Ion release results showed that Sr2+,Mg2+ and Si4+ ions kept leaching out within 10 days’ immersion. The degradable Si3N4 bioceramics with adequate strength and biologically beneficial sintering ad- ditives show the promise for load bearing biomedical applications, such as spinal fusion.

Place, publisher, year, edition, pages
2018. Vol. 38, no 4, p. 2110-2119
National Category
Natural Sciences Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-331879DOI: 10.1016/j.jeurceramsoc.2017.10.003ISI: 000424716700136OAI: oai:DiVA.org:uu-331879DiVA, id: diva2:1150463
Funder
Carl Tryggers foundation Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2018-08-12Bibliographically approved
In thesis
1. Spark plasma sintered ZrO2-SiO2 glass ceramics and Si3N4 bioceramics
Open this publication in new window or tab >>Spark plasma sintered ZrO2-SiO2 glass ceramics and Si3N4 bioceramics
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis focuses on elaboration and characterization of two types of bioceramics: one is ZrO2-SiO2 nanocrystalline glass ceramic (NCGC) for dental application. The goal is to develop new ZrO2-SiO2 NCGCs with a combination of high strength and high translucency; the other is biodegradable Si3N4 ceramics for spinal fusion. This project aims to improve the osteointergration property of Si3N4 ceramics. Translucent glass ceramics typically suffer from impaired mechanical properties, compared to full-ceramics. We presented a method of obtaining ZrO2-SiO2 NCGCs, with a microstructure of monocrystalline ZrO2 nanoparticles (NPs), embedded in an amorphous SiO2 matrix. Raw powders containing different ZrO2 contents were prepared by the sol-gel method, followed by the spark plasma sintering (SPS). The NCGC with a composition of 35%ZrO2-65%SiO2 (molar ratio, 35Zr) was transparent. Tetragonal ZrO2 NPs were spherical with a diameter of 20–40 nm. The average flexural strength of 35Zr NCGC was 234 MPa. To improve the flexural strength, NCGCs with compositions of 45%ZrO2-55%SiO2 (45Zr), 55%ZrO2-45%SiO2 (55Zr), 65%ZrO2-35%SiO2 (65Zr) were also elaborated. All NCGCs showed high translucency. The flexural strength of the NCGCs significantly increased with the increase of ZrO2 content, achieving as high as 1014 MPa for 65Zr NCGC.  ZrO2 NPs in 65Zr NCGC were ellipsoidal and had a core-shell structure with a thin Zr/Si interfacial layer as the shell. Some of the ZrO2 NPs were connected and formed ZrOnanofibers. Moreover, the ZrOnanofibers were orderly stacked in short-range to form the 3D nano-architecture. The high flexural strength of the 65Zr NCGC mainly originates from synergistic strengthening effects of the thin Zr/Si interfacial layer and 3D stacked nano-architecture. Regarding biodegradable Si3N4 bioceramics, we used a ternary sintering additive of SrO, MgO and SiO2.   The mechanical properties of the developed Si3N4 bioceramics were comparable to those of traditional Si3N4 ceramics. Sr2+, Mg2+, and Si4+ ions released from the intergranular glass phase after immersion in solution, indicating that the developed Si3N4 bioceramics showed certain biodegradable ability. These ions enhanced the proliferation and differentiation of preosteoblasts. Meanwhile, the ionic dissolution products did not show any toxic effects to the development or physiology of zebrafish embryos.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2018. p. 70
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1710
Keywords
ZrO2-SiO2 glass ceramic, high-strength, translucency, 3D nano-architecture, Si3N4 bioceramic, biodegradable, spark plasma sintering
National Category
Ceramics
Research subject
Materials Science
Identifiers
urn:nbn:se:uu:diva-357128 (URN)978-91-513-0419-9 (ISBN)
Public defence
2018-10-10, Häggsalen, 10132, Ångström, Lägerhyddsvägen 1, Uppsala, 09:00 (English)
Opponent
Supervisors
Funder
Carl Tryggers foundation
Available from: 2018-09-18 Created: 2018-08-12 Last updated: 2018-10-02

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Fu, LeEngqvist, HåkanXia, Wei

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