uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Second-look resection for primary stage T1 bladder cancer: a population-based study
Lund Univ, Dept Translat Med, SE-20502 Malmo, Sweden.;Skane Univ Hosp, Dept Urol, SE-20502 Malmo, Sweden..
Sahlgrens Univ Hosp, Dept Urol, Gothenburg, Sweden..
Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden..
Lund Univ, Dept Translat Med, SE-20502 Malmo, Sweden.;Skane Univ Hosp, Dept Urol, SE-20502 Malmo, Sweden..
Show others and affiliations
2017 (English)In: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813, Vol. 51, no 4, 301-307 p.Article in journal (Refereed) Published
Abstract [en]

Objective: This study aimed to evaluate the use of second-look resection (SLR) in stage T1 bladder cancer (BC) in a population-based Swedish cohort. Materials and methods: All patients diagnosed with stage T1 BC in 2008-2009 were identified in the Swedish National Registry for Urinary Bladder Cancer. Registry data on TNM stage, grade, primary treatment and pathological reports from the SLR performed within 8weeks of the primary transurethral resection were validated against patient charts. The endpoint was cancer-specific survival (CSS). Results: In total, 903 patients with a mean age of 74years (range 28-99 years) were included. SLR was performed in 501 patients (55%), who had the following stages at SLR: 172 (35%) T0, 83 (17%) Ta/Tis, 210 (43%) T1 and 26 (5%) T2-4. The use of SLR varied from 18% to 77% in the six healthcare regions. Multiple adjuvant intravesical instillations were given to 420 patients (47%). SLR was associated with intravesical instillations, age younger than 74 years, discussion at multidisciplinary tumour conference, G3 tumour and treatment at high-volume hospitals. Patients undergoing SLR had a lower risk of dying from BC (hazard ratio 0.62, 95% confidence interval 0.45-0.84, p<.0022). Five-year CSS rates were as follows, in patients with the indicated tumours at SLR (p=.001): 82% in those with T1, 90% in T0, 90% in Ta/Tis and 56% in T2-4. Conclusions: There are large geographical differences in the use of SLR in stage T1 BC in Sweden, which are presumably related to local treatment traditions. Patients treated with SLR have a high rate of residual tumour but lower age, which suggests that a selection bias affects CSS.

Place, publisher, year, edition, pages
2017. Vol. 51, no 4, 301-307 p.
Keyword [en]
Bladder cancer, cancer-specific survival, population-based, second-look resection, stage T1
National Category
Cancer and Oncology Urology and Nephrology
Identifiers
URN: urn:nbn:se:uu:diva-331915DOI: 10.1080/21681805.2017.1303846ISI: 000405483400012PubMedID: 28398113OAI: oai:DiVA.org:uu-331915DiVA: diva2:1150690
Funder
Swedish Cancer Society, CAN 2015/1155
Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2017-10-19Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Malmström, Per-Uno

Search in DiVA

By author/editor
Malmström, Per-Uno
By organisation
Urology
In the same journal
Scandinavian journal of urology
Cancer and OncologyUrology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 10 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf