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Curcumin Suppresses Tumor Growth and Angiogenesis in Human Glioma Cells Through Modulation of Vascular Endothelial Growth Factor/Angiopoietin-2/Thrombospondin-1 Signaling
Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China..
Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China..
Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China..
Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China..
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2017 (English)In: CNS & Neurological Disorders: Drug Targets, ISSN 1871-5273, E-ISSN 1996-3181, Vol. 16, no 3, 346-350 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To investigate the effect of curcumin on tumor growth and angiogenesis of human gliomas and identify the underlying molecular mechanisms. Methods: A mouse xenograft glioma model was established by subcutaneously inoculating tumor cell aggregates derived from the U87 cell line. Mice were treated with 0.01ml/g body weight of curcumin or saline. Tumor volume was measured. Microvessel density was assessed by CD34 immunostaining, and angiogenesis by immunohistochemical staining of vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) and thrombospondin 1 (TSP-1). Results: At 28 days after treatment, tumor weights in the curcumin-treated group were much smaller than in the control group (0.23 +/- 0.11g vs. 0.44 +/- 0.15g p < 0.05), resulting in a 45.8% inhibition of tumor growth. Curcumin also markedly inhibited microvessel density. Expression of VEGF and Ang-2 was inhibited by curcumin, whereas TSP-1 expression was up-regulated. Conclusion: This study shows that curcumin inhibits tumor growth by inhibiting VEGF/Ang-2/TSP-1-mediated angiogenesis in a xenograft glioma mouse model.

Place, publisher, year, edition, pages
2017. Vol. 16, no 3, 346-350 p.
Keyword [en]
Curcumin, glioma, angiogenesis, vascular endothelial growth factor
National Category
Pharmacology and Toxicology Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-331958DOI: 10.2174/1871527315666160902144513ISI: 000405316600013OAI: oai:DiVA.org:uu-331958DiVA: diva2:1151048
Funder
Swedish Foundation for Strategic Research
Available from: 2017-10-20 Created: 2017-10-20 Last updated: 2017-10-20Bibliographically approved

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Sharma, Hari ShankerSharma, Aruna

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Anaesthesiology and Intensive Care
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