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Antagonistically pleiotropic allele increases lifespan and late-life reproduction at the cost of early-life reproduction and individual fitness
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.ORCID iD: 0000-0001-5602-1933
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2017 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 284, no 1856, article id 20170376Article in journal (Refereed) Published
Abstract [en]

Evolutionary theory of ageing maintains that increased allocation to early-life reproduction results in reduced somatic maintenance, which is predicted to compromise longevity and late-life reproduction. This prediction has been challenged by the discovery of long-lived mutants with no loss of fecundity. The first such long-lived mutant was found in the nematode worm Caenorhabditis elegans. Specifically, partial loss-of-function mutation in the age-1 gene, involved in the nutrient-sensing insulin/insulin-like growth factor signalling pathway, confers longevity, as well as increased resistance to pathogens and to temperature stress without appreciable fitness detriment. Here, we show that the long-lived age-1(hx546) mutant has reduced fecundity and offspring production in early-life, but increased fecundity, hatching success, and offspring production in late-life compared with wild-type worms under standard conditions. However, reduced early-life performance of long-lived mutant animals was not fully compensated by improved performance in late-life and resulted in reduced individual fitness. These results suggest that the age-1(hx546) allele has opposing effects on early-life versus late-life fitness in accordance with antagonistic pleiotropy (AP) and disposable soma theories of ageing. These findings support the theoretical conjecture that experimental studies based on standing genetic variation underestimate the importance of AP in the evolution of ageing.

Place, publisher, year, edition, pages
ROYAL SOC , 2017. Vol. 284, no 1856, article id 20170376
Keywords [en]
ageing, senescence, life history
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-331255DOI: 10.1098/rspb.2017.0376ISI: 000405955300010OAI: oai:DiVA.org:uu-331255DiVA, id: diva2:1151644
Funder
EU, European Research Council, AGINGSEXDIFF 260885, HAPSELA 336633Swedish Research Council, 2013-04828Available from: 2017-10-24 Created: 2017-10-24 Last updated: 2017-10-24Bibliographically approved

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Maklakov, Alex ACarlsson, HanneLind, Martin I.Hinas, AndreaImmler, Simone

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Maklakov, Alex ACarlsson, HanneLind, Martin I.Hinas, AndreaImmler, Simone
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Animal ecologyDepartment of Medical Biochemistry and MicrobiologyEvolutionary Biology
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