uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy
Karolinska Inst, Dept Physiol & Pharmacol, Div Pharmacogenet, Drug Resistance Unit, Stockholm, Sweden..
Karolinska Inst, Dept Physiol & Pharmacol, Div Pharmacogenet, Drug Resistance Unit, Stockholm, Sweden..
Karolinska Inst, Dept Physiol & Pharmacol, Div Pharmacogenet, Drug Resistance Unit, Stockholm, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Dept Pharmacol, Unit Pharmacokinet & Drug Metab, Gothenburg, Sweden..
Show others and affiliations
2017 (English)In: Pharmacogenomics (London), ISSN 1462-2416, E-ISSN 1744-8042, Vol. 18, no 10, 981-985 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To investigate the potential involvement of the hepatic ATP-binding cassette transporters MRP2 and MDR1 in the disposition of lumefantrine (LUM) among patients with uncomplicated Plasmodium falciparum malaria.

Materials & methods: The tag SNPs MDR1/ABCB1 C3435T and MRP2/ABCC2 C1515Y were determined in two artemether-LUM clinical trials, including a pharmacokinetic/pharmacodynamic study focused on the treatment phase (72 h), and an efficacy trial where day 7 (D-7) LUM levels were measured.

Results: The 1515YY genotype was significantly associated with higher (p < 0.01) LUM D-7 concentrations (median 1.42 mu M), compared with 0.77 mu M for 1515CY and 0.59 mu M for 1515CC. No significant influence of the MDR1/ABCB1 C3435T was found.

Conclusion: LUM body disposition may be influenced by MRP2/ABCC2 genotype.

Place, publisher, year, edition, pages
FUTURE MEDICINE LTD , 2017. Vol. 18, no 10, 981-985 p.
Keyword [en]
ABCC2/MRP2, ACT, artemether, Coartem (R), disposition, lumefantrine, malaria
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-331253DOI: 10.2217/pgs-2017-0032ISI: 000405697300006PubMedID: 28639487OAI: oai:DiVA.org:uu-331253DiVA: diva2:1151649
Funder
Swedish Research Council, VR-2014-3134Sida - Swedish International Development Cooperation Agency, SWE-2009-2165
Available from: 2017-10-24 Created: 2017-10-24 Last updated: 2017-10-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Mårtensson, Andreas

Search in DiVA

By author/editor
Mårtensson, Andreas
By organisation
International Maternal and Child Health (IMCH)
In the same journal
Pharmacogenomics (London)
Pharmaceutical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 22 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf