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On the use of ion-crosslinked nanocellulose hydrogels for wound healing solutions: Physicochemical properties and application-oriented biocompatibility studies
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanotechnology and Functional Materials)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanotechnology and Functional Materials)ORCID iD: 0000-0001-5196-4115
Rise Bioeconomy.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanotechnology and Functional Materials)ORCID iD: 0000-0002-5496-9664
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2017 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 174, 299-308 p.Article in journal (Refereed) Published
Abstract [en]

Calcium ion-crosslinked nanofibrillated cellulose (NFC) hydrogels were investigated as potential materials for wound healing dressings. The physicochemical properties of the hydrogels were examined by rheology and water retention tests. Skin cells and monocytes were selected for application-oriented bio-compatibility studies. The NFC hydrogels presented entangled fibrous networks and solid-like behavior. Water retention tests showed the material's potential to maintain a suitable moist environment for different type of wounds. The hydrogels did not affect dermal fibroblasts monolayer cultures upon directcontact, as cell monolayers remained intact after application, incubation and removal of the materials. Inflammatory response studies with blood-derived mononuclear cells revealed the inert nature of the hydrogels in terms of cytokine secretion and reactive oxygen species production. Results highlight the great potential of ion-crosslinked NFC hydrogels for the development of advanced wound dressings, where further functionalization of the material could lead to improved properties towards the healing of specific wound types.

Place, publisher, year, edition, pages
2017. Vol. 174, 299-308 p.
Keyword [en]
Nanofibrillated cellulose, Inflammation, Fibroblasts, Mononuclear cells
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
URN: urn:nbn:se:uu:diva-332126DOI: 10.1016/j.carbpol.2017.06.073ISI: 000407696800032PubMedID: 28821071OAI: oai:DiVA.org:uu-332126DiVA: diva2:1152311
Funder
Swedish Research Council Formas
Available from: 2017-10-24 Created: 2017-10-24 Last updated: 2017-11-13Bibliographically approved

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Basu, AlexLindh, JonasStrömme, MariaFerraz, Natalia

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