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Patients with lymphatic malformations who receive the immunostimulant OK-432 experience excellent long-term outcomes
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 11, 1169-73 p.Article in journal (Refereed) Published
Abstract [en]

AIM: Sclerotherapy is the primary treatment for lymphatic malformations. The aim of this study was to evaluate the long-term outcome in patients with lymphatic malformations treated with the immunostimulant OK-432 as a sclerosant.

METHODS: Between 1998 and 2013, we enrolled 131 of 138 eligible patients treated with OK-432 for lymphatic malformations in a retrospective study. The malformations were categorised according to the International Society for the Study of Vascular Anomalies. The outcome was assessed with a clinical examination and a questionnaire.

RESULTS: The lymphatic malformations were localised to the head/neck (60%), the trunk (20%) and the extremities (6%) or involved with more than one region (14%). Patients with microcystic (10%), macrocystic (21%) and mixed lymphatic malformations (69%) underwent a median number of three, two and two injection treatments, respectively. The median age at the first injection was 3.4 years. Good or excellent clinical outcomes were seen in 70% of the patients. The number of injections, previous treatment and lesion localisation, but not time to follow-up and cyst size, predicted the clinical outcome.

CONCLUSION: OK-432 treatment resulted in a successful outcome in 70% of patients with lymphatic malformations. The long-term outcome was comparable to the short-term outcome.

Place, publisher, year, edition, pages
2015. Vol. 104, no 11, 1169-73 p.
Keyword [en]
Lymphatic malformation, OK-432, Sclerotherapy, Surgery
National Category
Surgery
Identifiers
URN: urn:nbn:se:uu:diva-332184DOI: 10.1111/apa.13086PubMedID: 26081020OAI: oai:DiVA.org:uu-332184DiVA: diva2:1152452
Available from: 2017-10-25 Created: 2017-10-25 Last updated: 2017-10-25

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