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Dietary L-tryptophan leaves a lasting impression on the brain and the stress response
Norwegian Inst Water Res NIVA, Gaustadalleen 21, N-0349 Oslo, Norway.;Univ Agder, Ctr Coastal Res, Postboks 422, N-4604 Kristiansand, Norway..
Norwegian Univ Life Sci, Dept Anim & Agr Sci, POB 1432, As, Norway..
Tech Univ Denmark, North Sea Ctr, Danish Inst Fisheries Res, Dept Marine Ecol & Aquaculture, POB 101, DK-9850 Hirtshals, Denmark..
Norwegian Univ Life Sci, Dept Anim & Agr Sci, POB 1432, As, Norway.;Tech Univ Denmark, North Sea Ctr, Danish Inst Fisheries Res, Dept Marine Ecol & Aquaculture, POB 101, DK-9850 Hirtshals, Denmark..
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2017 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 117, no 10, 1351-1357 p.Article in journal (Refereed) Published
Abstract [en]

Comparative models suggest that effects of dietary tryptophan (Trp) on brain serotonin (5-hydroxytryptamine; 5-HT) neurochemistry and stress responsiveness are present throughout the vertebrate lineage. Moreover, hypothalamic 5-HT seems to play a central role in control of the neuroendocrine stress axis in all vertebrates. Still, recent fish studies suggest long-term effects of dietary Trp on stress responsiveness, which are independent of hypothalamic 5-HT. Here, we investigated if dietary Trp treatment may result in long-lasting effects on stress responsiveness, including changes in plasma cortisol levels and 5-HT neurochemistry in the telencephalon and hypothalamus of Atlantic salmon. Fish were fed diets containing one, two or three times the Trp content in normal feed for 1 week. Subsequently, fish were reintroduced to control feed and were exposed to acute crowding stress for 1 h, 8 and 21 d post Trp treatment. Generally, acute crowding resulted in lower plasma cortisol levels in fish treated with 3xTrp compared with 1xTrp- and 2xTrp-treated fish. The same general pattern was reflected in telencephalic 5-HTergic turnover, for which 3xTrp-treated fish showed decreased values compared with 2xTrp-treated fish. These long-term effects on post-stress plasma cortisol levels and concomitant 5-HT turnover in the telencephalon lends further support to the fact that the extrahypothalamic control of the neuroendocrine stress response is conserved within the vertebrate lineage. Moreover, they indicate that trophic/structural effects in the brain underlie the effects of dietary Trp treatment on stress reactivity.

Place, publisher, year, edition, pages
Cambridge University Press, 2017. Vol. 117, no 10, 1351-1357 p.
Keyword [en]
L-Tryptophan, Long-term effects, Monoamines
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-330052DOI: 10.1017/S0007114517001428ISI: 000404987900002PubMedID: 28625179OAI: oai:DiVA.org:uu-330052DiVA: diva2:1155200
Available from: 2017-11-07 Created: 2017-11-07 Last updated: 2017-11-07Bibliographically approved

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Winberg, Svante

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