uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Northeast African genomic variation shaped by the continuity of indigenous groups and Eurasian migrations
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.ORCID iD: 0000-0002-8160-9621
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
Dept. of Linguistic and Cultural Evolution, Max Planck Institute for the Science of Human History, Jena, Germany..
Show others and affiliations
2017 (English)In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 13, no 8, e1006976Article in journal (Refereed) Published
Abstract [en]

Northeast Africa has a long history of human habitation, with fossil-finds from the earliest anatomically modern humans, and housing ancient civilizations. The region is also the gateway out of Africa, as well as a portal for migration into Africa from Eurasia via the Middle East and the Arabian Peninsula. We investigate the population history of northeast Africa by genotyping similar to 3.9 million SNPs in 221 individuals from 18 populations sampled in Sudan and South Sudan and combine this data with published genome-wide data from surrounding areas. We find a strong genetic divide between the populations from the northeastern parts of the region (Nubians, central Arab populations, and the Beja) and populations towards the west and south (Nilotes, Darfur and Kordofan populations). This differentiation is mainly caused by a large Eurasian ancestry component of the northeast populations likely driven by migration of Middle Eastern groups followed by admixture that affected the local populations in a north-to-south succession of events. Genetic evidence points to an early admixture event in the Nubians, concurrent with historical contact between North Sudanese and Arab groups. We estimate the admixture in current-day Sudanese Arab populations to about 700 years ago, coinciding with the fall of Dongola in 1315/1316 AD, a wave of admixture that reached the Darfurian/Kordofanian populations some 400-200 years ago. In contrast to the northeastern populations, the current-day Nilotic populations from the south of the region display little or no admixture from Eurasian groups indicating long-term isolation and population continuity in these areas of northeast Africa.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE , 2017. Vol. 13, no 8, e1006976
National Category
Genetics Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-333162DOI: 10.1371/journal.pgen.1006976ISI: 000408763800042PubMedID: 28837655OAI: oai:DiVA.org:uu-333162DiVA: diva2:1155291
Available from: 2017-11-07 Created: 2017-11-07 Last updated: 2017-12-13Bibliographically approved
In thesis
1.
The record could not be found. The reason may be that the record is no longer available or you may have typed in a wrong id in the address field.

Open Access in DiVA

fulltext(1771 kB)2 downloads
File information
File name FULLTEXT01.pdfFile size 1771 kBChecksum SHA-512
10e587e4056037a03558910ef78c40b73d3cbbddb1accc441b629953eae1d7dc2cc6751141eacfd12eb386422d062f5e7a9fa6b7dd661d35aef37bc82d2fd9b3
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedhttp://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006976#abstract0

Authority records BETA

Schlebusch, Carina M.Günther, TorstenJakobsson, Mattias

Search in DiVA

By author/editor
Hollfelder, NinaSchlebusch, Carina M.Günther, TorstenJakobsson, Mattias
By organisation
Evolution and Developmental BiologyScience for Life Laboratory, SciLifeLab
In the same journal
PLOS Genetics
GeneticsEvolutionary Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 2 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 25 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf