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Affibody Molecules in Biotechnological and Medical Applications
KTH Royal Inst Technol, Div Prot Technol, SE-10691 Stockholm, Sweden..
KTH Royal Inst Technol, Div Prot Technol, SE-10691 Stockholm, Sweden..
KTH Royal Inst Technol, Div Prot Technol, SE-10691 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Affibody AB, Gunnar Asplunds Alle 24, SE-17169 Solna, Sweden..
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2017 (English)In: Trends in Biotechnology, ISSN 0167-7799, E-ISSN 1879-3096, Vol. 35, no 8, 691-712 p.Article, review/survey (Refereed) Published
Abstract [en]

Affibody molecules are small (6.5-kDa) affinity proteins based on a three-helix bundle domain framework. Since their introduction 20 years ago as an alternative to antibodies for biotechnological applications, the first therapeutic affibody molecules have now entered clinical development and more than 400 studies have been published in which affibody molecules have been developed and used in a variety of contexts. In this review, we focus primarily on efforts over the past 5 years to explore the potential of affibody molecules for medical applications in oncology, neurodegenerative, and inflammation disorders, including molecular imaging, receptor signal blocking, and delivery of toxic payloads. In addition, we describe recent examples of biotechnological applications, in which affibody molecules have been exploited as modular affinity fusion partners.

Place, publisher, year, edition, pages
2017. Vol. 35, no 8, 691-712 p.
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Medical Biotechnology
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URN: urn:nbn:se:uu:diva-333328DOI: 10.1016/j.tibtech.2017.04.007ISI: 000405847200005PubMedID: 28514998OAI: oai:DiVA.org:uu-333328DiVA: diva2:1157252
Available from: 2017-11-15 Created: 2017-11-15 Last updated: 2017-11-15Bibliographically approved

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Frejd, Fredrik Y.

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