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Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors
Univ Crete, Sch Med, Dept Hematol, Iraklion, Greece..
Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece..
Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece..
Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece..
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2017 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, E-ISSN 1029-2403, Vol. 58, no 12, 2926-2933 p.Article in journal (Refereed) Published
Abstract [en]

Chronic idiopathic neutropenia (CIN) is an acquired disorder of granulopoiesis characterized by female predominance and mostly uncomplicated course. Crucial to CIN pathophysiology is the presence of activated T lymphocytes with myelosuppressive properties in both peripheral blood (PB) and bone marrow (BM). We systematically profiled the T cell receptor beta chain (TRB) gene repertoire in CD8(+) cells of 34 CIN patients through subcloning/Sanger sequencing analysis of TRBV-TRBD-TRBJ gene rearrangements. Remarkable repertoire skewing and oligoclonality were observed, along with shared clonotypes between different patients, alluding to antigen selection. Cross-comparison of our sequence dataset with public TRB sequence databases revealed that CIN may rarely share common immunogenetic features with other entities, however, the CIN TRB repertoire is largely disease-biased. Overall, these findings suggest that CIN may be driven by long-term exposure to a restricted set of specific CIN-associated antigens.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 58, no 12, 2926-2933 p.
Keyword [en]
Chronic idiopathic neutropenia, T cell receptor, antigen selection
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-333418DOI: 10.1080/10428194.2017.1324154ISI: 000406290000018PubMedID: 28535087OAI: oai:DiVA.org:uu-333418DiVA: diva2:1157425
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2017-11-16Bibliographically approved

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Stamatopoulos, Kostas

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