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Recurrent papillary craniopharyngioma with BRAFV600E mutation treated with neoadjuvant-targeted therapy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
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2017 (English)In: Acta Neurochirurgica, ISSN 0001-6268, E-ISSN 0942-0940Article in journal (Refereed) Epub ahead of print
Abstract [en]

Craniopharyngiomas are histologically benign but locally aggressive tumors in the sellar region that may cause devastating neurological and endocrine deficits. They tend to recur following surgery with high morbidity; hence, postoperative radiotherapy is recommended following sub-total resection. BRAFV600E mutation is the principal oncogenic driver in the papillary variant of craniopharyngiomas. Recently, a dramatic tumor reduction has been reported in a patient with BRAFV600E mutated, multiply recurrent papillary craniopharyngioma using a combination therapy of BRAF inhibitor dabrafenib and MEK inhibitor trametinib. Here, we report on near-radical reduction of a growing residual BRAFV600E craniopharyngioma using the same neoadjuvant therapy.

Place, publisher, year, edition, pages
2017.
Keyword [en]
BRAFV600E, Craniopharyngioma, RAF-inhibitor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-333691DOI: 10.1007/s00701-017-3311-0PubMedID: 28918496OAI: oai:DiVA.org:uu-333691DiVA: diva2:1157461
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2017-11-16

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