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Functionalization of bone implants with nanodiamond particles and angiopoietin-1 to improve vascularization and bone regeneration
Med Univ Innsbruck, Dept Craniomaxillofacial & Oral Surg, Maximilianstr 10, A-6020 Innsbruck, Austria..
Med Univ Innsbruck, Dept Craniomaxillofacial & Oral Surg, Maximilianstr 10, A-6020 Innsbruck, Austria..
Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany..
Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany..
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2017 (English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 5, no 32, 6629-6636 p.Article in journal (Refereed) Published
Abstract [en]

One of the major challenges in bone tissue engineering is adequate vascularization within bone substituents for nutrients and oxygen supply. In this study, the production and results of a new, highly functional bone construct consisting of a commercial three-dimensional beta-tricalcium phosphate scaffold (beta-TCP, ChronOS (R)) and hydrophilic, functionalized nanodiamond (ND) particles are reported. A 30-fold increase in the active surface area of the ChronOS + ND scaffold was achieved after modification with ND. In addition, immobilization of angiopoietin-1 (Ang-1) via physisorption within the beta-TCP + ND scaffold retained the bioactivity of the growth factor. Homogeneous distribution of the ND and Ang-1 within the core of the three-dimensional scaffold was confirmed using ND covalently labelled with Oregon Green. The biological responses of the beta-TCP + ND scaffold with and without Ang-1 were studied in a sheep calvaria critical size defect model showing that the beta-TCP + ND scaffold improved the blood vessel ingrowth and the beta-TCP + ND + ND + Ang-1 scaffold further promoted vascularization and new bone formation. The results demonstrate that the modification of scaffolds with tailored diamond nanoparticles is a valuable method for improving the characteristics of bone implants and enables new approaches in bone tissue engineering.

Place, publisher, year, edition, pages
2017. Vol. 5, no 32, 6629-6636 p.
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Materials Chemistry
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URN: urn:nbn:se:uu:diva-333753DOI: 10.1039/c7tb00723jISI: 000407684800019OAI: oai:DiVA.org:uu-333753DiVA: diva2:1157773
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2017-11-16Bibliographically approved

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Larsson, Karin

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