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Endoplasmic reticulum is the sorting core facility in the Golgi-lacking protozoan Giardia lamblia
Univ Nacl Cordoba, CONICET, INIMEC, Inst Invest Med Mercedes & Martin Ferreyra, Cordoba, Argentina.;Weill Cornell Med, Dept Med, Div Hematol & Med Oncol, 1300 York Ave,Room C-640, New York, NY 10065 USA..
Univ Nacl Cordoba, CONICET, INIMEC, Inst Invest Med Mercedes & Martin Ferreyra, Cordoba, Argentina..
Univ Nacl Cordoba, CONICET, INIMEC, Inst Invest Med Mercedes & Martin Ferreyra, Cordoba, Argentina..
Fiocruz Ba, Ctr Pesquisas Goncalo Moniz, Serv Microscopia Eletron, Salvador, BA, Brazil..
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2017 (English)In: Traffic: the International Journal of Intracellular Transport, ISSN 1398-9219, E-ISSN 1600-0854, Vol. 18, no 9, p. 604-621Article in journal (Refereed) Published
Abstract [en]

Our understanding of protein and lipid trafficking in eukaryotic cells has been challenged by the finding of different forms of compartmentalization and cargo processing in protozoan parasites. Here, we show that, in the absence of a Golgi compartment in Giardia, proteins destined for secretion are directly sorted and packaged at specialized ER regions enriched in COPII coatomer complexes and ceramide. We also demonstrated that ER-resident proteins are retained at the ER by the action of a KDEL receptor, which, in contrast to other eukaryotic KDEL receptors, showed no interorganellar dynamic but instead acts specifically at the limit of the ER membrane. Our study suggests that the ER-exit sites and the perinuclear ER-membranes are capable of performing protein-sorting functions. In our view, the description presented here suggests that Giardia adaptation represents an extreme example of reductive evolution without loss of function.

Place, publisher, year, edition, pages
2017. Vol. 18, no 9, p. 604-621
Keywords [en]
ceramide, coatomer, encystation, secretory pathway
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-333748DOI: 10.1111/tra.12501ISI: 000407677200004OAI: oai:DiVA.org:uu-333748DiVA, id: diva2:1157800
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2018-01-13Bibliographically approved

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Svärd, Staffan

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