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High insulin-like growth factor-binding protein-1 (IGFBP-1) is associated with low relative muscle mass in older women
Karolinska Inst, Natl Inst Environm Med, Unit Nutr Epidemiol, Box 210, S-17177 Stockholm, Sweden..
Karolinska Inst, Natl Inst Environm Med, Unit Nutr Epidemiol, Box 210, S-17177 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.ORCID iD: 0000-0003-2815-1217
Univ Southern Denmark, Dept Publ Hlth, Environm Med, Winslows Vej 17, Odense, Denmark..
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2017 (English)In: Metabolism: Clinical and Experimental, ISSN 0026-0495, E-ISSN 1532-8600, Vol. 73, 36-42 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Skeletal muscles serve several important roles in maintaining good health. Insulin like growth factor-1 (IGF-1) is a promoter of protein synthesis in skeletal muscle. Its binding protein, Insulin-like growth factor-binding protein-1 (IGFBP-1) can be one determinant of IGF-1 activity. In the present study we investigate the association between serum IGFBP-1 and muscle mass.

Design: Cross-sectional analysis of 4908 women, between 55 and 85 years old, participating in the Swedish Mammography Cohort-Clinical.

Methods: We defined low relative muscle mass (LRMM) as an appendicular lean mass divided by height squared of less than 5.45 (kg/m(2)), assessed by dual energy x-ray absorptiometry. IGFBP-1 was measured by radioimmunoassay. Logistic regression was used to calculate odds-ratios of LRMM across quartiles of IGFBP-1.

Results: The odds of LRMM increased across quartiles of IGFBP-1. In the age-adjusted model the odds-ratio (OR) of LRMM was 3.41 (95% CI: 2.55-4.56), comparing the highest to the lowest quartile. This estimate was attenuated in multivariate models (OR: 1.84, 95% CI: 1.34-2.53), mainly due to inclusion of fat mass index.

Conclusion: Women with higher IGFBP-1 were more likely to have a low relative muscle mass. High IGFBP-1 may be a marker of a catabolic state.

Place, publisher, year, edition, pages
W B SAUNDERS CO-ELSEVIER INC , 2017. Vol. 73, 36-42 p.
Keyword [en]
Insulin-like growth factor binding, protein 1, Body composition, Muscle, skeletal, Aged
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-333700DOI: 10.1016/j.metabol.2017.04.013ISI: 000406984200004PubMedID: 28732569OAI: oai:DiVA.org:uu-333700DiVA: diva2:1158709
Funder
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and WelfareEU, Horizon 2020, 633589
Available from: 2017-11-21 Created: 2017-11-21 Last updated: 2017-11-21Bibliographically approved

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