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Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study.
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2017 (English)In: Journal of Cardiothoracic and Vascular Anesthesia, ISSN 1053-0770, E-ISSN 1532-8422, Vol. 31, no 6, p. 2065-2071Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate whether changes in muscle tissue perfusion measured with positron emission tomography would be reflected by parallel changes in muscle tissue oxygen saturation (StO2) measured using near-infrared spectroscopy during high and low blood flow levels achieved using cardiopulmonary bypass (CPB) in an animal model.

DESIGN: A prospective, randomized study.

SETTING: Research laboratory, single institution.

PARTICIPANTS: Eight pigs (69-71 kg).

INTERVENTIONS: In anesthetized pigs, normothermic CPB was established with a blood flow of 60 mL/kg/min for 1 hour. Thereafter, a low blood flow of either 47.5 or 35 mL/kg/min was applied for 1 hour followed by a blood flow of 60 mL/kg/min for an additional hour. Regional StO2 was measured continuously by placing a near-infrared spectroscopy electrode on the skin above the gracilis muscle of the noncannulated back leg. Muscle tissue perfusion was measured using positron emission tomography with (15)O-labeled water during spontaneous circulation and the different CPB blood flows. Systemic oxygen consumption was estimated by measurement of venous saturation and lactate levels.

MEASUREMENTS AND MAIN RESULTS: The results showed profound systemic ischemia during low CPB blood flow. StO2 remained high until muscle tissue perfusion decreased to about 50%, after which StO2 paralleled the linear decrease in muscle tissue perfusion.

CONCLUSION: In an experimental CPB animal model, StO2 was stable until muscle tissue perfusion was reduced by about 50%, and at lower blood flow levels, there was almost a linear relationship between StO2 and muscle tissue perfusion.

Place, publisher, year, edition, pages
2017. Vol. 31, no 6, p. 2065-2071
Keyword [en]
animal study, cardiopulmonary bypass, muscle tissue perfusion, near-infrared spectroscopy, positron emission tomography, regional blood flow
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-334174DOI: 10.1053/j.jvca.2017.03.027ISI: 000418210800024PubMedID: 28693932OAI: oai:DiVA.org:uu-334174DiVA: diva2:1158880
Funder
Swedish Heart Lung Foundation
Available from: 2017-11-21 Created: 2017-11-21 Last updated: 2018-02-05Bibliographically approved

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Larsson, Anders

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Anaesthesiology and Intensive CareHedenstierna laboratory
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