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Detection of late complications after endovascular abdominal aortic aneurysm repair and implications for follow-up
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (kärlkirurgi)ORCID iD: 0000-0001-6156-8669
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Kärlkirurgi)
(kärlkirurgi)
(kärlkirurgi)
(English)Manuscript (preprint) (Other academic)
National Category
Surgery
Research subject
Surgery
Identifiers
URN: urn:nbn:se:uu:diva-334329OAI: oai:DiVA.org:uu-334329DiVA: diva2:1159250
Available from: 2017-11-22 Created: 2017-11-22 Last updated: 2017-12-04
In thesis
1. Endovascular aortic aneurysm repair: Aspects of follow-up and complications
Open this publication in new window or tab >>Endovascular aortic aneurysm repair: Aspects of follow-up and complications
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Endovascular aortic aneurysm repair (EVAR) is the procedure of choice in most patients with abdominal aortic aneurysm. The drawbacks of EVAR are a higher rate of complications and frequent need for reinterventions, requiring regular postoperative follow-up. Non-stratified follow-up may have a deleterious effect on patients and the health care system. The aim of this thesis is to develop strategies that can stratify the EVAR follow-up programme according to an individual patient´s risk profile.

Study I, an international multicentre study of all abdominal aortic aneurysm (AAA) patients with EVAR in three centres (2000 to 2011) demonstrated a lower rate of late complications and reinterventions in patients with sac shrinkage during the first postoperative year, compared to the non-shrinkage group.

Study II, an international multicentre study of patients treated for a ruptured aortic aneurysm with EVAR in three centres (2000 to 2012) demonstrated that ruptured EVAR (rEVAR) in patients with hostile anatomy is associated with a high rate of graft-related complications, reinterventions and increased overall mortality.

Study III, a two-centre cohort study of 326 patients with EVAR (2001 to 2012), with first postoperative computerised tomographic angiography (CTA) within one year of the operation. Patients with adequate proximal and distal sealing zones and no endoleak in the first postoperative CTA had significantly lower risk for AAA-related complications and reinterventions up to five years postoperatively.

Study IV, studied all complications and reinterventions in a two-centre cohort study of all EVAR patients (1998 to 2012), One-fourth of the patients in the study developed complications during a mean follow-up of five years. Most complications were asymptomatic imaging-detected. Ultrasound could detect most of the clinically significant complications.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2018. 89 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1402
Keyword
abdominal aortic aneurysm, EVAR, rEVAR surveillance
National Category
Surgery
Research subject
Surgery
Identifiers
urn:nbn:se:uu:diva-334369 (URN)978-91-513-0167-9 (ISBN)
Public defence
2018-01-19, Gustavianum, Akademigatan 3, 753 10 Uppsala, Sverige, Uppsala, 13:15 (English)
Opponent
Supervisors
Available from: 2017-12-22 Created: 2017-11-23 Last updated: 2017-12-22

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