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A pathology atlas of the human cancer transcriptome
KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.;Danish Tech Univ, Ctr Biosustainabil, Copenhagen, Denmark.;Royal Inst Technol, AlbaNova Univ Ctr, KTH, Sch Biotechnol, Stockholm, Sweden..
KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden..
KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology. KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
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2017 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 357, no 6352, eaan2507Article in journal (Refereed) Published
Abstract [en]

Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2017. Vol. 357, no 6352, eaan2507
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-334302DOI: 10.1126/science.aan2507ISI: 000407793600028OAI: oai:DiVA.org:uu-334302DiVA: diva2:1159296
Funder
Swedish Cancer SocietyScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceKnut and Alice Wallenberg FoundationSwedish Research Council
Available from: 2017-11-22 Created: 2017-11-22 Last updated: 2017-11-22Bibliographically approved

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Sjöstedt, EvelinaMattsson, Johanna Sofia MargaretaGlimelius, BengtSjöblom, TobiasEdqvist, Per-Henrik DDjureinovic, DijanaMicke, PatrickLindskog, CeciliaPonten, Fredrik

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Sjöstedt, EvelinaMattsson, Johanna Sofia MargaretaGlimelius, BengtSjöblom, TobiasEdqvist, Per-Henrik DDjureinovic, DijanaMicke, PatrickLindskog, CeciliaPonten, Fredrik
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