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Identification of the adenovirus type 2 C-168 protein
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. (Lind)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
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2017 (English)In: Virus Research, ISSN 0168-1702, E-ISSN 1872-7492, Vol. 238, 110-113 p.Article in journal (Refereed) Published
Abstract [en]

A hitherto predicted but undetected protein, C-168, in adenovirus type 2 (Ad2) has been identified using mass spectrometry (MS) based proteomics. The gene of this 17.7 kDa protein is located on the forward strand in the major late transcription unit between base pairs 9294 and 9797. A tryptic peptide, derived from the C-terminal part of the protein, was identified with high amino acid sequence coverage. A candidate splice site for the corresponding mRNA is also presented. The protein sequence is unusual with repeats of serine, glycine and arginine. A bioinformatics prediction of protein function and localization is presented.

Place, publisher, year, edition, pages
2017. Vol. 238, 110-113 p.
Keyword [en]
C-168, Adenovirus type 2, Mass spectrometry, Identification, Sequence comparison
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-334102DOI: 10.1016/j.virusres.2017.06.013ISI: 000408077500015PubMedID: 28629901OAI: oai:DiVA.org:uu-334102DiVA: diva2:1159947
Funder
Åke Wiberg Foundation, M14-0127Magnus Bergvall Foundation, 2015-01200; 2016-01675Carl Tryggers foundation , CST 15:57
Available from: 2017-11-24 Created: 2017-11-24 Last updated: 2017-12-21

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Zhao, HongxingKonzer, AnneFalk, AlexanderPettersson, UlfBergström Lind, Sara

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Zhao, HongxingKonzer, AnneFalk, AlexanderPettersson, UlfBergström Lind, Sara
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Science for Life Laboratory, SciLifeLabAnalytical ChemistryMedicinsk genetik och genomikDepartment of Immunology, Genetics and Pathology
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Virus Research
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