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Enzymatic degradation of hyaluronan hydrogels with different capacity for in situ bio-mineralization
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, People's Republic of China.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
2018 (English)In: Biopolymers, ISSN 0006-3525, E-ISSN 1097-0282, Vol. 109, no 2, article id e23090Article in journal (Refereed) Published
Abstract [en]

In situ cross-linked hyaluronan (HA) hydrogels with different capacities for biomineralization were prepared and their enzymatic degradation was monitored. Covalent incorporation of bisphosphonates (BPs) into HA hydrogel results in the increased stiffness of the hydrogel in comparison with the unmodified HA hydrogel of the same cross-linking density. The rate of enzymatic degradation of HABP hydrogel was significantly lower than the rate of degradation of control HA hydrogel in vitro. This effect is observed only in the presence of calcium ions that strongly bind to the matrix-anchored BP groups and promote further mineralization of the matrix. The degradation of the hydrogels was followed by noninvasive fluorescence measurements enabled after mild and chemoselective labeling of cross-linkable HA derivatives with a fluorescent tag.

Place, publisher, year, edition, pages
2018. Vol. 109, no 2, article id e23090
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-334854DOI: 10.1002/bip.23090ISI: 000428629000004OAI: oai:DiVA.org:uu-334854DiVA, id: diva2:1160873
Funder
EU, FP7, Seventh Framework ProgrammeAvailable from: 2017-11-28 Created: 2017-11-28 Last updated: 2018-06-04Bibliographically approved

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Shi, LiyangOssipov, Dmitri A.

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